| Project/Area Number |
23791126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | IL-33 / mast cell / vasculitis / apoptosis / なし |
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| Research Abstract |
The levels of Interleukin (IL)-33 were not elevated in the serum obtained from patients with vasculitis including ANCA-associated vasculitis. The regulation of MC survival by cytokines such as IL-3, SCF, IL4, and IL-10 have been demonstrated in prior studies. Given the newly found importance of IL-33 in MC immune functions, including cytokine production and granule maturation, we examined its effect on MC survival. We analyzed the effects of IL-33 on MC proliferation, survival and apoptosis. We have demonstrated that IL-33 prevents apoptosis of mouse bone marrow derived MCs (mBMMCs) induced by growth factor deprivation in vitro. This effect could represent a new mechanism by which IL-33 producing cells, such as fibroblasts, support the maintenanceof tissue mastocytosis.
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