Inhibitory effect of IL-16 on allergic diseases
| Project/Area Number |
23791129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo University of Agriculture and Technology (2011) |
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Principal Investigator |
KAJIWARA Naoki 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 (70453917)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アレルギー / 炎症 / インターロイキン-16 / サイトカイン |
|---|
| Research Abstract |
This study aims to examine the role of IL-16 produced by CD8^+ T cells in contact dermatitis. Rag-2-deficient mice reconstituted with IL-16-deficient CD8^+ T cells exhibited severe late-phase inflammatory response and most of mice died around 7 days after hapten application. IL-17A concentration was significantly elevated in sera of IL-16-deficient CD8^+ T cells-transferred Rag2-deficient mice. In addition, increase of GOT activity and decrease of albumin/globulin ratio were observed in sera of these mice. These results indicate that IL-16 produced by CD8^+ T cells plays an inhibitory role in late-phase reaction of contact dermatitis, suggesting the existence of immunomodulatory mechanism by CD8^+ regulatory T cells.
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Report
(3 results)
Research Products
(4 results)
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[Presentation] ITCによる接触皮膚炎におけるIL-16の役割2012
Author(s)
梶原直樹, 大保木啓介, Hardy Kornfeld, 奥村康, 斎藤博久, 中江進, 芝崎太
Organizer
Conference for BioSignal and Medicine (CBSM)2012
Place of Presentation
ホテル近鉄アクアヴィラ伊勢志摩
Related Report
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[Presentation] FITCによる接触皮膚炎におけるIL-16の役割2011
Author(s)
梶原直樹, 大保木啓介, 森田英明, Hardy Kornfeld, 奥村康, 斎藤博久, 中江進, 大森啓太郎, 田中あかね, 松田浩珍
Organizer
Conference for BioSignal and Medicine (CBSM)2011
Place of Presentation
軽井沢プリンスホテルウエスト
Related Report
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