Role of Innate immunity on the exacerbation of bronchial asthma via influenza virus infection
Project/Area Number |
23791131
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
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Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | インフルエンザウイルス / 気管支喘息 / 肺傷害 / 線維化 / エラスターゼ / 喘息 / コラーゲン / II型肺胞上皮 / インフルエンザ / 急性呼吸不全 |
Research Abstract |
Influenza virus is the reason of acute exacerbation bronchial asthma. However, it was lack of understanding for this mechanism. First, we have utilized mouse models of bronchial asthma induced by ovalbumin to experimentally examine a possible aggregation between influenza virus and asthma. We could not find any difference of clinical outcome, accumulation of inflammatory cells and Th1/Th2 related cytokines between normal and asthma mouse after influenza virus infection. We, next, examined whether tissue remodeling was observed after severe inflammation by influenza virus infection. Mice were inoculated non-lethal dose of influenza virus, histopathological analysis presented bronchiectasis and peribronchial collagen diposition and collagen level in the lung was significantly elevated compared to normal mice at the day 35 post-infection. This model could be a novel experimental tool for approaching the pathogenic mechanism of bronchial remodeling after sever inflammation.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Impact of psm-mec in the mobile genetic element on the clinical characteristics and outcome of SCCmec-II methicillin-resistant Staphylococcus aureus bacteraemia in Japan2014
Author(s)
Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Hatta M, Endo S, Kanamori H, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M
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Journal Title
Clin Microbiol Infect
Volume: (in press)
Issue: 9
Pages: 912-919
DOI
Related Report
Peer Reviewed
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[Journal Article] Characteristics of infectious diseases in hospitalized patients during the early phase after the 2011 great East Japan earthquake : pneumonia as a significant reason for hospital care2013
Author(s)
Aoyagi T, Yamada M, Kunishima H, Tokuda K, Yano H, Ishibashi N, Hatta M, Endo S, Arai K, Inomata S, Gu Y, Kanamori H, Kitagawa M, Hirakata Y, Kaku M
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Journal Title
Chest
Volume: 143(2)
Issue: 2
Pages: 349-56
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of High Mobility Group Box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome2013
Author(s)
Kudo D, Toyama M, Aoyagi T, Akahori Y, Yamamoto H, Ishii K, Kanno E, Maruyam R, Kaku M, Kushimoto S, Kawakami K
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Journal Title
Clin. Exp. Immunol
Volume: (In press)
Issue: 2
Pages: 276-87
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome2013
Author(s)
Kudo D, Toyama M, Aoyagi T, Akahori Y, Yamamoto H, Ishii K, Kanno E, Maruyama R, Kaku M, Kushimoto S, Kawakami K
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Journal Title
Clin Exp Immunol.
Volume: 173
Pages: 276-87
Related Report
Peer Reviewed
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[Presentation] Improvement in lipopolysaccharide-induced fulminate acute respiratory distress syndrome model by etoposide plus steroid therapy2014
Author(s)
T Aoyagi, Y Sato, K Kawakami, M Toyama, K Ishii, H Kanamori, S Endo, M Hatta, Y Gu, K Tokuda, H Yano, M Kaku
Organizer
American Thorasic Society 2014
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Association between psm-mec on the Mobile Genetic Element and Clinical Manifestation of Methicillin-Resistant Staphylococcus aureus Infection2013
Author(s)
Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Endo S, Hatta M, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M
Organizer
IDweek
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Lung fibrosis after acute lung injury caused by H1N1 influenza virus infection in mice2013
Author(s)
Aoyagi T, Kawakami K, Ishii K, Endo S, Kanamori H, Gu Y, Hatta M, Tokuda K, Yano H, Kunishima H, Kaku M
Organizer
American Thoracic Society 2013
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] A novel ALI/ARDS experimental animal model caused by H1N1 influenza virus2013
Author(s)
Aoyagi T, Kawakami K, Ishii K, Endo S, Kanamori H, Gu Y, Hatta M, Tokuda K, Yano H, Kunishima H, Kaku M
Organizer
NIH-Tohoku University-JSPS Symposium
Place of Presentation
Sendai, Japan
Related Report
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[Presentation] Association between psm-mec on the Mobile Genetic Element and Clinical Manifestation of Methicillin-Resistant Staphylococcus aureus Infection2013
Author(s)
T. Aoyagi, None C. Kaito, None K. Sekimizu, None Y. Omae, None Y. Saito, None H. Mao, None S. Inomata, None S. Endo, None M. Hatta, None Y. Gu, None K. Tokuda, None H. Yano, None M. Kitagawa, None M. Kaku, None
Organizer
ID week 2013
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Candida albicans versus non-albicans Candida in general wards at the tertiary University hospital in Japan2012
Author(s)
Aoyagi T, Kunishima H, Kanamori H, Endo S, Hatta M, Gu Y, Yamada M, Tokuda K, Yano H, Kitagawa M, Kaku M
Organizer
8th International Healthcare Infection Society (HIS) Conference and Federation of Infection Societies (FIS) annual conference
Place of Presentation
Liverpool, UK
Related Report
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[Presentation] Analysis of infectious diseases in the aftermath of the 2011 Tohoku earthquake and tsunami : the threat of pneumonia to survivors2011
Author(s)
Aoyagi T, Yamada M, Kunishima H, Tokuda K, Yano H, Ishibashi N, Hatta M, Endo S, Arai K, Kanamori H, Kitagawa M, Hirakata Y, and Kaku M
Organizer
The 49th Annual Meeting of the Infectious Diseases Society of America (IDSA)
Place of Presentation
Boston, USA
Related Report