• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basis research in evolutionary mechanism of H5N1 highly pathogenic avian influenza viruses

Research Project

Project/Area Number 23791134
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionOsaka University

Principal Investigator

WATANABE Yohei  大阪大学, 微生物病研究所, 助教 (50452462)

Co-Investigator(Renkei-kenkyūsha) IKUTA Kazuyoshi  大阪大学, 医学系研究科, 招へい教授 (60127181)
NAKAYA Takaaki  京都府立医科大学, 医学研究科, 教授 (80271633)
DAIDOJI Tomo  京都府立医科大学, 医学研究科, 助教 (80432433)
SUZUKI Yasuo  中部大学, 生命健康科学部, 教授 (00046278)
TAKAHASHI Kazuo  大阪府立公衆衛生研究所, 感染症部, 部長 (10171472)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords国際感染症 / ウイルス学 / 人獣共通感染症 / インフルエンザウイルス / インフルエンザ / 鳥インフルエンザウイルス / 人獣共同感染症 / 変異 / ヒト適応性 / エジプト / H5N1
Outline of Final Research Achievements

We have searched mutations that H5N1 highly pathogenic avian influenza viruses acquired during their dissemination in Egypt. The results showed that specific sublineage viruses in Egypt have acquired HA mutations that enhanced their human-type receptor binding affinity. The mutations also conferred a higher virulence in the infected mice. Our finding suggested that H5N1 viruses could acquire mutations that increase the infectivity toward humans during their transmission in birds.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (10 results) (of which Invited: 3 results) Remarks (2 results)

  • [Journal Article] Control of endemic influenza virus H5N1 in view of viral and host diversity.2013

    • Author(s)
      Watanabe, Y., Ibrahim, M.S., and Ikuta, K.
    • Journal Title

      EMBO Rep.

      Volume: 14 Issue: 2 Pages: 117-122

    • DOI

      10.1038/embor.2012.212

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antigenic analysis of highly pathogenic avian influenza virus H5N1 sublineage co-circulating in Egypt.2012

    • Author(s)
      Watanabe, Y., Ibrahim, M.S., Ellakany, H.F., Kawashita, N., Daidoji, T., Takagi, T., Yasunaga, T., Nakaya, T., and Ikuta, K.
    • Journal Title

      J. Gen. Virol.

      Volume: 93 Issue: 10 Pages: 2215-2226

    • DOI

      10.1099/vir.0.044032-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Avian Influenza A virus (H5N1) : the changing nature2012

    • Author(s)
      Yohei Watanabe
    • Journal Title

      Trends in Microbiology

      Volume: 20 Issue: 1 Pages: 11-20

    • DOI

      10.1016/j.tim.2011.10.003

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt2011

    • Author(s)
      Y. Watanabe, M. S. Ibrahim, H. F. Ellakany, N. Kawashita, R. Mizuike, H. Hiramatsu, N. Sriwilaijaroen, T. Takagi, Y. Suzuki and K. Ikuta
    • Journal Title

      PLoS Pathogens

      Volume: 7 Issue: 5 Pages: e1002068-e1002068

    • DOI

      10.1371/journal.ppat.1002068

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic diversification of H5N1 highly pathogenic avian influenza Avirus during replication in wild ducks2011

    • Author(s)
      Watanabe, Y., Ibrahim, M.S., Ellakany, H.F., Abd El-Hamid, H.S., Ikuta, K.
    • Journal Title

      J.Gen.Virol.

      Volume: 92 Issue: 9 Pages: 2105-2110

    • DOI

      10.1099/vir.0.032623-0

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] H5N1鳥インフルエンザウイルスの初代ヒト呼吸器上皮細胞における遺伝子多様化についての解析2015

    • Author(s)
      渡邊洋平
    • Organizer
      Fourth Negative Strand Virus-Japan
    • Place of Presentation
      沖縄
    • Year and Date
      2015-01-19 – 2015-01-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] H5N1高病原性鳥インフルエンザウイルスclade 2.2.1 HAのヒト適応変異2014

    • Author(s)
      渡邊洋平、荒井泰葉、大道寺智、川下理日人、Madiha S. Ibrahim、平松宏明、纐纈律子、高橋和郎、奥野良信、中屋隆明、鈴木康夫、塩田達雄、生田和良
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] H5N1高病原性鳥インフルエンザウイルスポリメラーゼにおけるヒト適応変異の探索2014

    • Author(s)
      荒井泰葉、Madiha S. Ibrahim、大道寺智、高橋和郎、中屋隆明、鈴木康夫、塩田達雄、塩田達雄、生田和良、渡邊洋平
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] PB2-627Kを有するclade2.2.1 H5N1高病原性鳥インフルエンザウイルスに対するHA変異導入がヒト呼吸器上皮における複製動態に与える影響の解析2014

    • Author(s)
      渡邊洋平
    • Organizer
      Third Negative Strand Virus-Japan Symposium
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report
  • [Presentation] エジプトにおける患者由来H5N1高病原性鳥インフルエンザウイルスHA遺伝子の変異解析2013

    • Author(s)
      渡邊洋平、Madiha S. Ibrahim、大道寺智、荒井泰葉、平松宏明、中屋隆明、鈴木康夫、生田和良
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] 鳥インフルエンザウイルスのヒト呼吸器上皮細胞に対する感染メカニズム2013

    • Author(s)
      大道寺智、渡邊洋平、Ibrahim Madiha S.、安木真世、丸山央峰、益田泰輔、新井史人、大場誠介、本田文江、生田和良、中屋隆明
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 海外流行地域におけるH5N1高病原性鳥インフルエンザウイルスの多様性獲得について2012

    • Author(s)
      渡邊洋平
    • Organizer
      第53回日本臨床ウイルス学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 高病原性鳥インフルエンザウイルスのヒト型レセプター結合性変異監視デバイス2012

    • Author(s)
      渡邊洋平、伊東哲男、Madiha S. Ibrahim、Hany F. Ellakany、Nongluk Sriwilaijaroen、平松宏明、林司、高橋忠伸、鈴木隆、生田和良、鈴木康夫
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] エジプトにおけるH5N1高病原性鳥インフルエンザウイルスの多様化について2012

    • Author(s)
      渡邊洋平
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt2011

    • Author(s)
      Yohei Watanabe
    • Organizer
      The XVth International Congress of Virology
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Research-status Report
  • [Remarks] 微生物病研究所主な研究成果webページ:

    • URL

      http://www.biken.osaka-u.ac.jp/topics.html

    • Related Report
      2011 Research-status Report
  • [Remarks] ウイルス免疫分野研究室webページ:

    • URL

      http://virology.biken.osaka-u.ac.jp/index.php

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi