| Project/Area Number |
23791137
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 肺炎 / 抗炎症 / HMGB1 / ネクローシス |
|---|
| Research Abstract |
We studied the effectiveness of anti-inflammatory therapeutic approaches against severe lung infections. Legionella induced necrotic cell death with releasing inflammatory mediator, HMGB1,via cathepsin B activation. Cathepsin B inhibitor or recombinant thrombomodulin improved the inflammatory findings and weight changes in the mouse model of severe Legionella infection. Thrombomodulin also contributed to the treatment of Staphylococcus aureus lung infection
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