Analysis of autism model rats exposed to thalidomide
| Project/Area Number |
23791167
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
OHKAWARA Takeshi 三重大学, 医学(系)研究科(研究院), 講師 (20469034)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自閉症 / 小脳 / サリドマイド / モノアミン |
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| Research Abstract |
We have shown that "our autism model rats" which exposed to thalidomide during pregnancy impair serotonergic system including raphe nucleus and show behavior abnormality to the offspring. Now we have also shown that exposure to thalidomide during pregnancy induces morphological abnormalities in the cerebellum to the offspring. However, monoamine contents in the hippocampus and striatum did not differ between control group and thalidomide-treated group.
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Report
(4 results)
Research Products
(6 results)
