Analysis of autism model rats exposed to thalidomide

• Project/Area Number: 23791167
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Mie University
• Principal Investigator: OHKAWARA Takeshi 三重大学, 医学(系)研究科(研究院), 講師 (20469034)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 自閉症 / 小脳 / サリドマイド / モノアミン

Research Abstract

We have shown that "our autism model rats" which exposed to thalidomide during pregnancy impair serotonergic system including raphe nucleus and show behavior abnormality to the offspring. Now we have also shown that exposure to thalidomide during pregnancy induces morphological abnormalities in the cerebellum to the offspring. However, monoamine contents in the hippocampus and striatum did not differ between control group and thalidomide-treated group.

Research Products

• [Presentation] 自閉症モデルラットにおける小脳のPurkinje細胞数の減少 (2013)
  • Author(s): 大河原剛、江藤みちる、成田正明
  • Organizer: 日本神経科学会
  • Place of Presentation: 国立京都国際会館(京都市左京区)
  • Year and Date: 2013-06-21
• [Presentation] 胎内でのウイルス感染モデルによるセロトニン神経系への影響―化学物質ばく露とのメカニズムの違い― (2013)
  • Author(s): 大河原剛、葛山貴士、江藤みちる、成田正明
  • Organizer: 日本解剖学会(シンポジウム)
  • Place of Presentation: サンポートホール高松(香川県高松市)
  • Year and Date: 2013-03-28
• [Presentation] 妊娠中のウイルス感染は、セロトニン神経に長期的毒性を引き起こし、その機序はサリドマイドやバルプロ酸によるそれとは異なる (2012)
  • Author(s): 大河原剛、葛山貴士、大薮明子、江藤みちる、櫻本新、太城康良、成田正明
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋国際会議場(名古屋市熱田区)
  • Year and Date: 2012-09-20
• [Presentation] Abnormalities in cerebellar Purkinje cells in autism model rats induced by thalidomide (2012)
  • Author(s): 大河原 剛
  • Organizer: 北米神経科学会
  • Place of Presentation: New Orleans
• [Presentation] 自閉症モデルラットにおける小脳のPurkinje細胞数の減少
  • Author(s): 大河原剛、江藤みちる、成田正明
  • Organizer: 日本神経科学会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
• [Remarks]
  • URL: http://www.medic.mie-u.ac.jp/develop_regener/