| Project/Area Number |
23791170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto University |
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Principal Investigator |
AWAYA Tomonari 京都大学, 大学院・医学研究科, 助教 (20589593)
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| Research Collaborator |
KATO Takeo 京都大学, 大学院医学研究科, 助教 (60422945)
HEIKE Toshio 京都大学, 大学院医学研究科, 教授 (90190173)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ES細胞 / Ips細胞 / 骨格筋 / 筋疾患 / 筋ジストロフィー / サテライト細胞 / 細胞治療 / 再生医療 / iPS細胞 / 骨格筋分化 / ヒト胚性幹細胞 / ヒト誘導多能性幹細胞 / 疾患特異的iPS細胞 |
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| Research Abstract |
We developed a novel skeletal myogenic differentiation protocol for human embryonic stem (ES) and induced pluripotent stem (iPS) cells in vitro. We also demonstrated the in vivoengraftment capacity of the generated cells in pre-damaged muscles of immunodeficient mice. These cells partially committed to muscle satellite cells as well, exhibiting long-term sustainable muscle reconstruction. These observations encourage the further use of human ES and iPS cells in regenerative medicine.
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