Research Project
Grant-in-Aid for Young Scientists (B)
Genome wide association studies have failed to identify genesthat strongly contribute to the pathogenesis of systemic lupus erythematosus (SLE) because SLE is a multifactorial disease. We found one Japanese consanguineous SLE family which consists of 3 affected and 1 unaffected sibling. To identify the underlying gene, we performed a positional cloning analysis and revealed one homozygous region (FSLE-2; 1.1Mb). Next we carried out exome resequencing in FSLE-2 region and identified a candidate gene. We are establishing a genetically modified mouse of the candidate gene to know the association of this gene with the pathogenesis of SLE.
All 2013 2012 2011
All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)
J Immunol
Volume: 188 Issue: 5 Pages: 2227-34
10.4049/jimmunol.1102586
iochem Biophys Res Commun
Volume: 418 Issue: 4 Pages: 701-707
10.1016/j.bbrc.2012.01.082
J Clin Invest
Volume: 121 Issue: 10 Pages: 4150-4160
10.1172/jci58414