Abnormalities of intracellular signaling in the cerebral cortex of neurodevelopmental disorder model mice.

• Project/Area Number: 23791188
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: SOUMIYA Hitomi 岐阜薬科大学, 薬学部, 助教 (20548713)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 大脳皮質 / 神経栄養因子

Research Abstract

The neurodeveloping disorder model mice were made by injection Poly I:C, a synthetic analog of double-stranded RNA, to pregnant mice. The Poly I:C- treated mice offspring didn’t learn cue-guided radial maze task efficiently. The number of pERK1/2 positive cells was significantly decreased in the cerebral cortex of Poly I:C-treated mice after the last task. The results obtained in this study suggest that the alterations of pERK1/2 expression in the cerebral cortex might cause the learning defect in the Poly I:C-treated mice.

Research Products

• [Journal Article] Antidepressant-like activity of 10-hydroxy-trans-2-decenoic Acid, a unique unsaturated Fatty Acid of royal j e l l y , i n s t r e s s - i n d u c i b l e depression-like mouse model. (2012)
  • Author(s): Ito S, Nitta Y, Fukumitsu H, Soumiya H, Ikeno K,Nakamura T, Furukawa S.
  • Journal Title: Evid Based Complement Alternat Med.2012 Pages: 139140-139140
  • Peer Reviewed
• [Journal Article] Antidepressant-like activity of 10-hydroxy-trans-2-decenoic Acid, a unique unsaturated Fatty Acid of royal jelly, in stress-inducible depression-like mouse model. (2012)
  • Author(s): Ito S, Nitta Y, Fukumitsu H, Soumiya H, Ikeno K, Nakamura T, Furukawa S.
  • Journal Title: Evid Based Complement Alternat Med. Volume: 2012 Pages: 139140-139140
  • Peer Reviewed
• [Journal Article] Prenatal immune challenge compromises development of upper-layer but not deeper-layer neurons of the mouse cerebral cortex. (2011)
  • Author(s): Soumiya H, Fukumitsu H, Furukawa S.
  • Journal Title: J Neurosci Res Volume: 89 Pages: 1342-1350
  • Peer Reviewed
• [Journal Article] Prenatal immune challenge compromises the normal course of neurogenesis during development of the mouse cerebral cortex. (2011)
  • Author(s): Soumiya H, Fukumitsu H, Furukawa S.
  • Journal Title: J Neurosci Res Volume: 89 Pages: 1575-1585
  • Peer Reviewed
• [Journal Article] Prenatal immune challenge compromises development of upper-layer but not deeper-layer neurons of the mouse cerebral cortex. (2011)
  • Author(s): Soumiya H, Fukumitsu H, Furukawa S.
  • Journal Title: J Neurosci Res. Volume: 89 Pages: 1342-1350
  • Peer Reviewed
• [Journal Article] Prenatal immune challenge compromises the normal course of neurogenesis during development of the mouse cerebral cortex. (2011)
  • Author(s): Soumiya H, Fukumitsu H, Furukawa S.
  • Journal Title: J Neurosci Res. Volume: 89 Pages: 1575-1585
  • Peer Reviewed