Identification of responsible gene(s) for congenital heart defect using the model mice of Down syndrome

Research Project

Project/Area Number	23791194
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pediatrics
Research Institution	Keio University
Principal Investigator	MIYAMOTO Kenichi 慶應義塾大学, 医学部, 特任助教 (00424185)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	ダウン症 / 心奇形 / ノックアウトマウス / Zfp295 / ヒト人工染色体 / 遺伝子量効果
Research Abstract	In this study, we focused on the congenital heart defect that is observed with relatively high frequency in the patients with Down syndrome, and attempted to generate the knockout mice of Zfp295 that is one of the candidate genes for Down syndrome congeni