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Research Project

Project/Area Number 23791198
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionTokyo Women's Medical University

Principal Investigator

SHIMIZU Mikiko  東京女子医科大学, 医学部, 助教 (40338968)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsチアノーゼ性先天性心疾患 / P-selectin / 低酸素血症 / フォンタン手術
Research Abstract

1. Platelet P-selectin expression was enhanced in patients with cyanotic congenital heart disease (CCHD). 2. Platelet aggregation was enhanced in patients with CCHD. 3. In patients with thromboembolism, platelet P-selectin expression was enhanced. 4. Factors related with platelet activation were cyanosis and Fontan operation. 5. Platelet activation was related with endothelial dysfunction, measured by serum thrombomodulin concentration.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 2011

All Journal Article (1 results) Presentation (4 results)

  • [Journal Article] 胎生期の動脈管を始めとした心血管におけるタンパク質発現の解析2011

    • Author(s)
      中西敏雄, 羽山恵美子, 勝部康弘
    • Journal Title

      (財)日本心臓血圧研究振興会(平成二十二年度研究業績集)

      Volume: 24 Pages: 17-21

    • Related Report
      2011 Research-status Report
  • [Presentation] 胎仔発達に伴う肺動脈・動脈管の発現タンパク質の変化2012

    • Author(s)
      羽山恵美子, 中西敏雄
    • Organizer
      第18回日本小児肺循環研究会
    • Place of Presentation
      笹川記念会館(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 膜電位依存性カリウムチャネル1.5の遺伝子多型における機能変化の検討2011

    • Author(s)
      羽山恵美子, 勝部康弘, 中西敏雄
    • Organizer
      第47回日本小児循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Naturally Occurring L138Q Mutation in the Voltage-gated Potassium Channel 1.5 Impairs the Channel Activity2011

    • Author(s)
      羽山恵美子, 勝部康弘, 中西敏雄
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Developmental Difference in Maturation of Sarcoplasmic Reticulum in the Large Blood Vessels Influences Their Contractility2011

    • Author(s)
      羽山恵美子, 中西敏雄
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      アメリカ, フロリダ
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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