The establishment of a novel diagnostic system of gastroesophageal reflux disease in neurologically impaired children

• Project/Area Number: 23791199
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kurume University
• Principal Investigator: FUKAHORI Suguru 久留米大学, 医学部, 助教 (90299488)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 先天性消化管疾患学 / 重症心身障碍児 / 胃食道逆流症 / 食道インピーダンス / 胃排出能 / C13呼気ガス分析

Research Abstract

Combined pH - Multichannel Intraluminal Impedance Measurements and 13C-acetate breathtest were conducted to 63 and 31 neurologically impaired (NI) children for 2 years, respectively. The results of the analysis of each device’s parameters were reported. NI children with pathological GERD showed more reflux episodes reaching proximal esophagus than the others. NI children after fundoplication might have slight esophageal dysmotility. All NI children showeddelayed gastric emptying.

Research Products

• [Journal Article] Yagi MPre and Post-operative Evaluation of Gastroesophageal Reflux and Esophageal Motility in Neurologically Impaired Children Using Combined pH - Multichannel (2013)
  • Author(s): Fukahori S, Asagiri K, Ishii S, Tanaka Y,Kojima S, Saikusa N, Koga Y, Yoshida M, Masui D, Komatsuzaki N, Seki Y
  • Journal Title: Intraluminal Impedance Measurements Pediatr Surg Int Volume: 29(6) Issue: 6 Pages: 545-51
  • DOI: 10.1007/s00383-013-3295-7
• [Journal Article] Pre and post-operative evaluation of gastroesophageal reflux and esophageal motility in neurologically impaired children using combined pH-multichannel intraluminal impedance measurements (2013)
  • Author(s): Fukahori S
  • Journal Title: Pediatric Surgery International Volume: 電子掲載
  • Peer Reviewed
• [Presentation] 24時間食道インピーダンスを用いた重症心身障碍児のGERDと食道運動機能の評価 (2013)
  • Author(s): 深堀 優
  • Organizer: 第9回消化管学会総会
  • Place of Presentation: 東京
• [Presentation] 八木 実24 時間食道インピーダンスを用いた重症心 身障がい児の GERD と食道運動機能の評価 (2012)
  • Author(s): 深堀 優 ,石井信二,浅桐公男, 田 中芳明,田中宏明,小島伸一郎,古賀義法, 升 井大介,小松崎尚子
  • Organizer: 第49回日本小児外科学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 重症心身障害者における胃排出能の検討 (2012)
  • Author(s): 石井信二,深堀優,八木実,小松崎尚子,吉田索,古賀義法,小島伸一郎,七種伸行,浅桐公男,田中芳明
  • Organizer: 第49回日本小児外科学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Kimio Asagiri and Yoshiaki TanakaEvaluation of Gastric Emptying measured by 13C-acetate breath test in NeurologicallyImpaired Children (2012)
  • Author(s): Shinji Ishii, Minoru Yagi, Suguru Fukahori, Naoko Komatsuzaki, Motomu Yoshida, Yoshinori Koga, Shinichiro Kojima, Nobuyuki Saikusa
  • Organizer: The 25thInternational Symposium on Paediatric Surgical Research London
  • Place of Presentation: UK
• [Presentation] Daisuke Masui, Naoko Komatsuzaki, and Minoru YagiPre and Post-operative Evaluation of Gastroesophageal Reflux and Esophageal motility in Neurologically Impaired Children Using Combined pH - Multichannel Intraluminal Impedance Measurements (2012)
  • Author(s): Suguru Fukahori, Kimio Asagiri, Shinji Ishii, Yoshiaki Tanaka, Shin-ichiro Kojima, Nobuyuki Saikusa, Yoshinori Koga, Motomu Yoshida
  • Organizer: The 25th International Symposium onPaediatric Surgical Research London
  • Place of Presentation: UK
• [Presentation] 24時間食道インピーダンスを用いた重症心身障碍児のGERDと食道運動機能の評価 (2012)
  • Author(s): 深堀 優
  • Organizer: 第49回日本小児外科学会総会
  • Place of Presentation: 東京
• [Presentation] 呼気ガス分析による胃排出能の経験 (2012)
  • Author(s): 石井信二
  • Organizer: 第49回日本小児外科学会総会
  • Place of Presentation: 東京
• [Presentation] Pre and post-operative evaluation of gastroesophageal reflux and esophageal motility in neurologically impaired children using combined pH-multichannel intraluminal impedance measurements (2012)
  • Author(s): Fukahori Suguru
  • Organizer: 25th International Symoosium on Pediatric Surgical Research
  • Place of Presentation: ロンドン
• [Presentation] Evaluation of Gastric Emptying Measured By C13-Acetate Breath Test in Neurologically Impaired Children (2012)
  • Author(s): Shinji Ishii
  • Organizer: 25th International Symoosium on Pediatric Surgical Research
  • Place of Presentation: ロンドン
• [Presentation] 24時間食道インピーダンスを用いた重症心身障がい児のGERDと食道運動機能の評価 (2012)
  • Author(s): 深堀 優
  • Organizer: 42回日本小児消化管機能研究会
  • Place of Presentation: 鹿児島
• [Presentation] 食道pHインピーダンス法を用いた小児胃食道逆流症の病態把握 (2011)
  • Author(s): 深堀優,小松崎尚子,升井大介,古賀義法,小島伸一郎,石井信二,田中宏明,浅桐公男,田中芳明,八木実
  • Organizer: 第8回日本消化管学会学術集会
  • Place of Presentation: 仙台
• [Presentation] The utility of esophageal combined pH - multichannel intraluminal impedance measurements: the experience of our institution and the new trial. (2011)
  • Author(s): 深堀 優
  • Organizer: 24th International Symposium on Paediatric Surgical Research
  • Place of Presentation: グラーツ/オーストリア
• [Presentation] The utility of esophageal combined pH - multichannel intraluminal impedance measurements: the experience of our institution and the new trial. (2011)
  • Author(s): 深堀 優
  • Organizer: 5th European Pediatric Motility Meeting
  • Place of Presentation: アムステルダム/オランダ
• [Presentation] Kimio Asagiri and Yoshiaki TanakaThe utility of esophageal combined pH - multichannel intraluminal impedance measurements: the experience of our institution and the new trial (2010)
  • Author(s): Suguru Fukahori, Minoru Yagi, Shinji Ishii, Daisuke Masui, Naoko Komatsuzaki, Yoshinori Koga, Shinichiro Kojima, Hiroaki Tanaka
  • Organizer: The 24th International Symposium onPaediatric Surgical Research Graz
  • Place of Presentation: Austria