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The clarification of molecular pathology of alternating hemiplegia of childhood.

Research Project

Project/Area Number 23791201
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionFukuoka University

Principal Investigator

ISHII Atsushi  福岡大学, 医学部, 助手 (90568825)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords小児神経 / 遺伝子 / ATP1A3 / てんかん / 不随意運動 / エクソーム解析 / イオンチャネル / 次世代シークエンサー / 小児神経疾患 / 麻痺発作 / 発達障害 / 国際情報交換 / チャネル / 小児交互性片麻痺 / ATP1A3 / パーキンソン病 / ジストニア / 全エクソーム / 麻痺 / 不随運動
Research Abstract

Alternating hemiplegia of childhood (AHC) has an onset of an abnormal eye movement during the early years of life and paroxysmal hemiplegia in the first year and a half. In addition, AHC has associated symptoms that are epilepsy and a variety of involuntary movements. There are not specific examination findings and established treatments.
Exome sequencing was performed for the 8 patients with typical AHC to identify a responsible gene. As a result, each patient harbored a heterozygous missense ATP1A3 mutation. These mutations were not found in their parents. We elucidated that a de novo heterozygous missense mutation in the ATP1A3 gene is a cause of AHC. In addition, we found out the significant correlation between phenotype and E815K mutation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (51 results)

All 2014 2013 2012 2011 Other

All Journal Article (30 results) (of which Peer Reviewed: 14 results,  Open Access: 1 results) Presentation (21 results) (of which Invited: 4 results)

  • [Journal Article] Intermediate form between alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism2014

    • Author(s)
      Sasaki M., Ishii A., Saito Y., Hirose S.
    • Journal Title

      Mov Disord

      Volume: 29(1) Pages: 153-154

    • Related Report
      2013 Final Research Report
  • [Journal Article] Distinct neurological disorders with ATP1A3 mutations2014

    • Author(s)
      Heinzen E. L., Arzimanoglou A., Brashear A., Clapcote S. J., Gurrieri F., Goldstein D. B., Johannesson S. H., Mikati M. A., Neville B., Nicole S., Ozelius L. J., Poulsen H., Schyns T., Sweadner K. J., van den Maagdenberg A., Vilsen B., for the A. T. P. A. Working Group
    • Journal Title

      Lancet Neurol

      Volume: 13(5) Pages: 503-514

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of nonsense mutation in GABRG2 with abnormal trafficking of GABAA receptors in severe epilepsy2014

    • Author(s)
      Ishii A., Kanaumi T., Sohda M., Misumi Y., Zhang B., Kakinuma N., Haga Y., Watanabe K., Takeda S., Okada M., Ueno S., Kaneko S., Takashima S., Hirose S.
    • Journal Title

      Epilepsy Res

      Volume: 108(3) Pages: 420-432

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genotype-phenotype correlations in alternating hemiplegia of childhood2014

    • Author(s)
      S asaki M., Ishii A., Saito Y., Morisada N., Iijima K., Takada S., Araki A., Tanabe Y., Arai H., Yamashita S., Ohashi T., Oda Y., Ichiseki H., Hirabayashi S., Yasuhara A., Kawawaki H., Kimura S., Shimono M., Narumiya S., Suzuki M., Yoshida T., Oyazato Y., Tsuneishi S., Ozasa S., Yokochi K., Dejima S., Akiyama T., Kishi N., Kira R., Ikeda T., Oguni H., Zhang B., Tsuji S., Hirose S.
    • Journal Title

      Neurology

      Volume: 82(6) Pages: 482-490

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effect of CYP2C19 polymorphisms on stiripentol administration in Japanese cases of Dravet syndrome.2014

    • Author(s)
      Kouga T, Shimbo H, Iai M, Yamashita S, Ishii A, Ihara Y, Hirose S, Yamakawa K, Osaka H.
    • Journal Title

      Brain & Development

      Volume: 印刷中 Issue: 2 Pages: 243-9

    • DOI

      10.1016/j.braindev.2014.04.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of nonsense mutation in GABRG2 with abnormal trafficking of GABA<sub>A</sub> receptors in severe epilepsy2014

    • Author(s)
      Ishii, A., Kanaumi, T., Sohda, M., Misumi, Y., Zhang, B., Kakinuma, N., Haga, Y., Watanabe, K., Takeda, S., Okada, M., Ueno, S., Kaneko, S., Takashima, S., Hirose, S.
    • Journal Title

      Epilepsy Res

      Volume: 108 Issue: 3 Pages: 420

    • DOI

      10.1016/j.eplepsyres.2013.12.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotype-Phenotype Correlations in Alternating Hemiplegia of Childhood2014

    • Author(s)
      Sasaki M, Ishii A, Saito Y, (中略), Tsuji S and Hirose S.
    • Journal Title

      Neurology

      Volume: 82 Issue: 6 Pages: 482-490

    • DOI

      10.1212/wnl.0000000000000102

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intermediate form between alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism.2014

    • Author(s)
      Sasaki M, Ishii A, Saito Y, Hirose S.
    • Journal Title

      Movement disorders

      Volume: 29 Issue: 1 Pages: 153-154

    • DOI

      10.1002/mds.25659

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct neurological disorders with ATP1A3 mutations.2014

    • Author(s)
      Heinzen, E.L.*, Arzimanoglou, A., Brashear, A., Clapcote, S.J., Gurrieri, F., Goldstein, D.B., Johannesson, S.H., Mikati, M.A., Neville, B., Nicole, S., Ozelius, L.J., Poulsen, H., Schyns, T., Sweadner, K.J., van den Maagdenberg, A., Vilsen, B., the ATP1A3 Working Group (included Ikeda, K.).
    • Journal Title

      Lancet Neurol.

      Volume: 13 Issue: 5 Pages: 503-514

    • DOI

      10.1016/s1474-4422(14)70011-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pancreatic Solid Pseudo-Papillary Tumor Detected After Abdominal Injury2013

    • Author(s)
      Ishii A., Yoshimura K., Ideguchi .h, Hirose S.
    • Journal Title

      Gastroenterology Research

      Volume: 6(2) Pages: 67-70

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of ATP1A3 mutations by exome sequencing as the cause of alternating hemiplegia of childhood in Japanese patients.2013

    • Author(s)
      Ishii A, Saito Y, Mitsui J, Ishiura H, Yoshimura J, Arai H, Yamashita S, Kimura S, Oguni H, Morishita S, Tsuji S, Sasaki M, Hirose S.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 2 Pages: e56120-e56120

    • DOI

      10.1371/journal.pone.0056120

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of PRRT2 for benign infantile epilepsy, infantile convulsions with choreoathetosis syndrome, and benign convulsions with mild gastroenteritis2013

    • Author(s)
      Ishii A., Yasumoto S., Ihara Y., Inoue T., Fujita T., Nakamura N., Ohfu M., Yamashita Y., Takatsuka H., Taga T., Miyata R., Ito M., Tsuchiya H., Matsuoka T., Kitao T., Murakami K., Lee W. T., Kaneko S., Hirose S.
    • Journal Title

      Brain Dev

      Volume: 35(6) Pages: 524-530

    • Related Report
      2013 Final Research Report
  • [Journal Article] A recurrent KCNT1 mutation in two sporadic cases with malignant migrating partial seizures in infancy2013

    • Author(s)
      Ishii A., Shioda M., Okumura A., Kidokoro H., Sakauchi M., Shimada S., Shimizu T., Osawa M., Hirose S., Yamamoto T.
    • Journal Title

      Gene

      Volume: 531(2) Pages: 467-471

    • Related Report
      2013 Final Research Report
  • [Journal Article] Newborn screening for Fabry disease in Japan : prevalence and genotypes of Fabry disease in a pilot study2013

    • Author(s)
      Inoue T., Hattori K., Ihara K., Ishii A., Nakamura K., Hirose S.
    • Journal Title

      J Hum Genet

      Volume: 58(8) Pages: 548-552

    • NAID

      10031195285

    • Related Report
      2013 Final Research Report
  • [Journal Article] 小児神経学の新たな展開ゲノム科学による病因不明・難治性小児神経疾患の病態解明への戦略2013

    • Author(s)
      石井敦士,廣瀬伸一
    • Journal Title

      日本小児科学会雑誌

      Volume: 117(9) Pages: 1383-1388

    • NAID

      10031195065

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genetic analysis of PRRT2 for benign infantile epilepsy, infantile convulsions with choreoathetosis syndrome, and benign convulsions with mild gastroenteritis.2013

    • Author(s)
      Ishii A, et al
    • Journal Title

      Brain and Development

      Volume: 35 Issue: 6 Pages: 524-30

    • DOI

      10.1016/j.braindev.2012.09.006

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A recurrent KCNT1 mutation in two sporadic cases with malignant migrating partial seizures in infancy.2013

    • Author(s)
      Ishii A, Shioda M, Okumura A, Kidokoro H, Sakauchi M, Shimada S, Shimizu T, Osawa M, Hirose S, Yamamoto T.
    • Journal Title

      Gene

      Volume: 531 Issue: 2 Pages: 467-71

    • DOI

      10.1016/j.gene.2013.08.096

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newborn screening for Fabry disease in Japan: Prevalence and genotypes of Fabry disease in a pilot study.2013

    • Author(s)
      Inoue T, Hattori K, Ihara K, Ishii A, Nakamura K, Hirose S
    • Journal Title

      J. Hum. Genet.

      Volume: 58 Issue: 8 Pages: 548-52

    • DOI

      10.1038/jhg.2013.48

    • NAID

      10031195285

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On the likelihood of SCN1A microdeletions or duplications in Dravet syndrome with missense mutation2012

    • Author(s)
      Shi X., Wang J., Kurahashi H., Ishii A., Higurashi N., Kaneko S., Hirose S.
    • Journal Title

      Brain Dev

      Volume: 34(8) Pages: 617-619

    • Related Report
      2013 Final Research Report
  • [Journal Article] KCNQ2 abnormality in BECTS : Benign childhood epilepsy with centrotemporal spikes following benign neonatal seizures resulting from a mutation of KCNQ22012

    • Author(s)
      Ishii A., Miyajima T., Kurahashi H., Wang J. W., Yasumoto S., Kaneko S., Hirose S.
    • Journal Title

      Epilepsy Res

      Volume: 102(1-2) Pages: 122-125

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prevalence of SCN1A mutations in children with suspected Dravet syndrome and intractable childhood epilepsy2012

    • Author(s)
      Wang J. W., Shi X. Y., Kurahashi H., Hwang S. K., Ishii A., Higurashi N., Kaneko S., Hirose S., Epilepsy Genetic Study Group Japan
    • Journal Title

      Epilepsy Res

      Volume: 102(3) Pages: 195-200

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【てんかん治療の最前線】てんかんの分子病態2012

    • Author(s)
      井原由紀子,石井敦士,日暮憲道,内田琢,中村友紀,友納優子,廣瀬伸一
    • Journal Title

      Medical Science Digest

      Volume: 38(7) Pages: 292-295

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【知っておきたいてんかん診療】てんかんと社会てんかんと遺伝子2012

    • Author(s)
      廣瀬伸一,日暮憲道,中村友紀,黄壽卿,石井敦士
    • Journal Title

      Modern Physician

      Volume: 32(3) Pages: 282-288

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【抑制性シナプスの基礎と臨床】疾患とその治療における抑制性シナプスの意義てんかんにおけるGABA受容体とK+チャネルの異常2012

    • Author(s)
      石井敦士,内田琢,中村友紀,廣瀬伸一
    • Journal Title

      Clinical Neuroscience

      Volume: 30(12) Pages: 1397-1400

    • Related Report
      2013 Final Research Report
  • [Journal Article] KCNQ2 abnormality in BECTS: benign childhood epilepsy with centrotemporal spikes following benign neonatal seizures resulting from a mutation of KCNQ2.2012

    • Author(s)
      Ishii A, Miyajima T, Kurahashi H, Wang JW, Yasumoto S, Kaneko S, Hirose S.
    • Journal Title

      Epilepsy reserch

      Volume: 102 Issue: 1-2 Pages: 122-5

    • DOI

      10.1016/j.eplepsyres.2012.07.011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of SCN1A mutations in children with suspected Dravet syndrome and intractable childhood epilepsy.2012

    • Author(s)
      Wang JW, Shi XY, Kurahashi H, Hwang SK, Ishii A, Higurashi N, Kaneko S, Hirose S,Epilepsy Genetic Study Group J.
    • Journal Title

      Epilepsy Res.

      Volume: 102(3) Issue: 3 Pages: 195-200

    • DOI

      10.1016/j.eplepsyres.2012.06.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] てんかんと遺伝子2012

    • Author(s)
      廣瀬伸一、日暮憲道、中村友紀、黄壽卿、石井敦士
    • Journal Title

      Modern Physician

      Volume: 32巻 Pages: 282-288

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【臨床に役立つてんかんの最新情報】てんかん遺伝子診断は臨床に役立つか?2011

    • Author(s)
      廣瀬伸一,日暮憲道,中村友紀,黄壽卿,石井敦士
    • Journal Title

      神経内科

      Volume: 74(5) Pages: 460-466

    • Related Report
      2013 Final Research Report
  • [Journal Article] On the likelihood of SCN1A microdeletions or duplications in Dravet syndrome with missense mutation2011

    • Author(s)
      Shi X, Wang J, Kurahashi H, Ishii A, Higurashi N, Kaneko s, Hirose S
    • Journal Title

      Brain Dev

      Volume: (in press) Issue: 8 Pages: 617-9

    • DOI

      10.1016/j.braindev.2011.11.005

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【臨床に役立つてんかんの最新情報】 てんかん遺伝子診断は臨床に役立つか?2011

    • Author(s)
      廣瀬伸一、日暮憲道、中村友紀、黄壽卿、石井敦士
    • Journal Title

      神経内科

      Volume: 74巻 Pages: 460-466

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 小児神経疾患のゲノム解析の現況と将来~てんかんとゲノム~2014

    • Author(s)
      石井敦士
    • Organizer
      第56回日本小児神経学会近畿地方会学会
    • Place of Presentation
      大阪市立総合医療センター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Identification of ATP1A3 mutations by exome sequencing as the cause of alternating hemiplegia of childhood in Japan2013

    • Author(s)
      Ishii A., Saito Y., Mitsui J., Ishiura H., Yoshimura J., Arai H., Yamashita S., Kimura S., Oguni H., Morishita S., Tsuji S., Sasaki M., Hirose S
    • Organizer
      30th International Epilepsy Congress
    • Place of Presentation
      (国際学会・シンポジウム)
    • Year and Date
      2013-06-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児交互性片麻痺の病因遺伝子であるATP1A3の同定と現状について2013

    • Author(s)
      石井敦士、佐々木征行、斎藤義朗、廣瀬伸一
    • Organizer
      第55回小児神経学会総会
    • Place of Presentation
      大分(国内学会・シンポジウム)
    • Year and Date
      2013-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児交互性片麻痺の責任遺伝子であるATP1A3の同定2013

    • Author(s)
      石井敦士、佐々木征行、廣瀬伸一
    • Organizer
      第474回日本小児科学会福岡地方会
    • Place of Presentation
      (国内学会・シンポジウム)
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児交互性片麻痺の原因遺伝子を見つける意義とは、新学術「ゲノム支援」2013

    • Author(s)
      石井敦士
    • Organizer
      公開シンポジウム「次世代ゲノム科学の最前線」
    • Place of Presentation
      京都大学(国内学会・シンポジウム)
    • Year and Date
      2013-02-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 1. Identification of ATP1A3 mutations by exome sequencing as the cause of alternating hemiplegia of childhood in Japan2013

    • Author(s)
      Atsushi Ishii, Yoshiaki Saito, Jun Mitsui, Hiroyuki Ishiura , Jun Yoshimura, Hidee Arai, Sumimasa Yamashita, Sadami Kimura, Hirokazu Oguni, Shinichi Morishita, Shoji Tsuji, Masayuki Sasaki, Shinichi Hirose
    • Organizer
      30th International Epilepsy Congress
    • Place of Presentation
      Montreal
    • Related Report
      2013 Annual Research Report
  • [Presentation] 2. 小児交互性片麻痺の病因遺伝子であるATP1A3の同定と現状について2013

    • Author(s)
      石井敦士、佐々木征行、廣瀬伸一
    • Organizer
      第55回日本小児神経学会総会
    • Place of Presentation
      大分市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミダゾラムが片麻痺発作抑制に有効であった小児交互性片麻痺の1 例2013

    • Author(s)
      荒木敦、田邉裕子、石井敦士、廣瀬伸一
    • Organizer
      第55回日本小児神経学会総会
    • Place of Presentation
      大分市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 家族性片麻痺性片頭痛2 型の母子例2013

    • Author(s)
      龍神布紀子、吉岡誠一郎、粟嶋勇也、西倉紀子、高野知行、竹内義博、石井敦士、廣瀬伸一
    • Organizer
      第55回日本小児神経学会総会
    • Place of Presentation
      大分市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児交互性片麻痺の責任遺伝子であるATP1A3の同定2013

    • Author(s)
      石井敦士、廣瀬伸一、佐々木征行
    • Organizer
      第476回福岡小児科学会地方会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 乳児痙攣、ICCA症候群、軽症胃腸炎に伴う痙攣でのPRRT2遺伝子の解析2013

    • Author(s)
      石井敦士
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of ATP1A3 mutations by exome sequencing as the cause of AHC in Japanese patients2012

    • Author(s)
      Ishii A.
    • Organizer
      Symposium ATP1A3 in Disease
    • Place of Presentation
      Brussels, Belgium(国際学会・シンポジウム)
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児交互性片麻痺の分子病態の解明2012

    • Author(s)
      石井敦士
    • Organizer
      24-7「脳形成異常を主とする発達期障害の病因・態と治療に関する研究」22-6「発達障害の診断および治療法開に関する臨床研究」班合同シンポジウム
    • Place of Presentation
      国立精神・神経医療研究センター(国内学会・シンポジウム)
    • Year and Date
      2012-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetic analysis of Alternating Hemiplegia of Childhood2012

    • Author(s)
      Ishii A., Saito Y., Sasaki M., Hirose S.
    • Organizer
      10th European Congress of Epileptology
    • Place of Presentation
      London(国際学会・シンポジウム)
    • Year and Date
      2012-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 遺伝子研究からのてんかんの分子病態の解明を目指して2012

    • Author(s)
      石井敦士
    • Organizer
      第22回遺伝医学セミナー
    • Place of Presentation
      ホテル阪急エキスポパーク(国内学会・シンポジウム)
    • Year and Date
      2012-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetic analysis of PRRT2 for benign infantile epilepsy, infantile convulsions with choleoathetosis syndrome, and benign convulsions with mild gastroenteritis2012

    • Author(s)
      Ishii A., Yasumoto S., Ihara Y., Inoue T., Fujita T., Nakamura N., Ohfu M., Lee WT., Kaneko S., Hirose S.
    • Organizer
      2012 Korea Epilepsy Congress
    • Place of Presentation
      Inchon(国際学会・シンポジウム)
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetic analysis of Alternating Hemiplegia of Childhood2012

    • Author(s)
      Atsushi Ishii, Yoshiaki Saito, Masayuki Sasaki, Shinichi Hirose
    • Organizer
      10th European Congress of Epileptology
    • Place of Presentation
      London
    • Related Report
      2012 Research-status Report
  • [Presentation] Genetic analysis of PRRT2 for benign infantile epilepsy, infantile convulsions with choleoathetosis syndrome, and benign convulsions with mild gastroenteritis2012

    • Author(s)
      Atsushi Ishii, Sawa Yasumoto, Yukiko Ihara, Takahito Inoue, Takako Fujita, Noriko Nakamura, Masaharu Ohfu, Wang-Tso Lee, Sunao Kaneko, and Shinichi Hirose
    • Organizer
      2012 Korea Epilepsy Congress
    • Place of Presentation
      Inchon
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification of ATP1A3 mutations by exome sequencing as the cause of AHC in Japanese patients.2012

    • Author(s)
      Atsushi Ishii
    • Organizer
      Symposium ATP1A3 in Disease.
    • Place of Presentation
      Belgium
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 遺伝子研究からのてんかんの分子病態の解明を目指して2012

    • Author(s)
      石井 敦士
    • Organizer
      第22回遺伝医学セミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 小児交互性片麻痺の原因遺伝子を見つける意義とは

    • Author(s)
      石井 敦士
    • Organizer
      新学術「ゲノム支援」公開シンポジウム「次世代ゲノム科学の最前線」
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2011-08-05   Modified: 2023-03-16  

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