Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
Mutations of SCN2A gene encoding voltage-gated sodium channel α2, Nav1.2, have been associated with neurodevelopmental disorders. We here demonstrate that mice with selective SCN2A deletion in forebrain neurons died within postnatal day 2 and developed no apparent behavioral seizures. The results indicate that Nav1.2 in forebrain neurons is essential to survival.
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