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Exploring genetic susceptibility to food allergy in innate and mucosal immunity genes

Research Project

Project/Area Number 23791204
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

HIROTA Tomomitsu  独立行政法人理化学研究所, 呼吸器疾患研究チーム, 研究員 (50435674)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords食物アレルギー / 関連遺伝子 / 自然免疫 / 粘膜免疫 / 遺伝子多型 / 疾患関連遺伝子
Research Abstract

The prevalence of food allergy has increased over the past two decades in Japan. To elucidate the pathological mechanisms underlying food allergy, we conducted case-control studies using 600 food allergy patients and 1900 controls. As a result, we identified a significant association between a SNP of IL13 gene and food allergy (p<0.01). In subgroup analysis, the association between the SNP of IL13 and food allergy was enhanced in subgroups patients with bronchial asthma and with atopic dermatitis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011

All Journal Article (19 results) (of which Peer Reviewed: 15 results) Presentation (5 results)

  • [Journal Article] Genome-wide association studies of allergic diseases2013

    • Author(s)
      Tamari Mayumi, Shota Tanaka, Tomomitsu Hirota
    • Journal Title

      Allergology International

      Volume: 62巻 Pages: 21-28

    • NAID

      130004477182

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-Wide Association Studies of Allergic Diseases2013

    • Author(s)
      Mayumi Tamari
    • Journal Title

      Allergology International

      Volume: 62 Issue: 1 Pages: 21-28

    • DOI

      10.2332/allergolint.13-RAI-0539

    • NAID

      130004477182

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations2012

    • Author(s)
      Chang WC, Lee CH, Hirota T. et al.
    • Journal Title

      PLoS One

      Volume: 7巻

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.2012

    • Author(s)
      Hirota T, Takahashi A, Kubo M, et al.
    • Journal Title

      Nature Genetics

      Volume: 44巻 Pages: 1222-1226

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルギーをめぐるトレンド ここが知りたい アレルギーの遺伝子解析入門2012

    • Author(s)
      広田朝光、田中翔太、角大治朗、玉利真由美
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: 10巻3号 Pages: 192-194

    • Related Report
      2012 Final Research Report
  • [Journal Article] A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population2012

    • Author(s)
      Kinose D, Ogawa E, Hirota T, Ito I, Kudo M, Haruna A, Marumo S, Hoshino Y, Muro S, Hirai T, Sakai H, Date H, Tamari M, Mishima M
    • Journal Title

      Respirology

      Volume: 17(1) Issue: 1 Pages: 164-71

    • DOI

      10.1111/j.1440-1843.2011.02069.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations2012

    • Author(s)
      Wei-Chiao Chang
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食物アレルギーの遺伝子多型 (特集 食物アレルギー研究の新たな展開)2011

    • Author(s)
      広田朝光、冨田かおり、玉利真由美
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55巻 Pages: 629-635

    • NAID

      40018904443

    • Related Report
      2012 Final Research Report
  • [Journal Article] 食物アレルギーのゲノム解析の現況(特集アトピー性疾患のゲノム研究 アップデート)2011

    • Author(s)
      広田朝光、冨田かおり、玉利真由美
    • Journal Title

      アレルギー・免疫

      Volume: 18巻9号 Pages: 56-62

    • NAID

      40018958753

    • Related Report
      2012 Final Research Report
  • [Journal Article] 解説(基礎) GWAS による疾患遺伝子の解明2011

    • Author(s)
      広田朝光、田中翔太、玉利真由美
    • Journal Title

      呼吸

      Volume: 31巻7号 Pages: 605-611

    • Related Report
      2012 Final Research Report
  • [Journal Article] Variants of C-C Motif Chemokine 22 (CCL22) Are Associated with Susceptibility to Atopic Dermatitis: Case-Control Studies2011

    • Author(s)
      Hirota T, Saeki H, Tomita K, et al.
    • Journal Title

      PLoS One

      Volume: 6巻

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011

    • Author(s)
      Harada M, Hirota T, Jodo Al, et al
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 44 Issue: 6 Pages: 787-793

    • DOI

      10.1165/rcmb.2009-0418oc

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lower FEV1 in non-COPD, nonasthmatic subjects : association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes2011

    • Author(s)
      Masuko H, et al.
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 6 Pages: 181-189

    • DOI

      10.2147/copd.s16383

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of nine novel loci associated with white blood cell subtypes in a Japanese population2011

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: 7 Issue: 6 Pages: e1002067-e1002067

    • DOI

      10.1371/journal.pgen.1002067

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1 : a longitudinal retrospective cohort study2011

    • Author(s)
      Masuko H, et al.
    • Journal Title

      BMC Med Genet

      Volume: 12 Issue: 1 Pages: 97-97

    • DOI

      10.1186/1471-2350-12-97

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations2011

    • Author(s)
      Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
    • Journal Title

      PLoS Genet

      Volume: 7(7) Issue: 7 Pages: 1002170-1002170

    • DOI

      10.1371/journal.pgen.1002170

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population2011

    • Author(s)
      Hirota, T., et.al.
    • Journal Title

      Nat Genet

      Volume: 43(9) Issue: 9 Pages: 893-6

    • DOI

      10.1038/ng.887

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association of GLCCI1 with asthma steroid treatment response2011

    • Author(s)
      Kelan G. Tantisira
    • Journal Title

      The New England Journal of Medicine

      Volume: 365 Issue: 13 Pages: 1173-1183

    • DOI

      10.1056/nejmoa0911353

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis : case-control studies2011

    • Author(s)
      Hirota, T., et.al.
    • Journal Title

      PLoS One

      Volume: 6(11) Issue: 11 Pages: e26987-e26987

    • DOI

      10.1371/journal.pone.0026987

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] シンポジウム3 アレルギー疾患のゲノムワイド関連解析の現況2012

    • Author(s)
      広田朝光
    • Organizer
      日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2012-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] A variant of filaggrin (FLG) are associated with susceptibility to food allergy in the Japanese population2012

    • Author(s)
      Tomomitsu Hirota
    • Organizer
      The American Society of Human Genetics
    • Place of Presentation
      Moscone Center, San Francisco, USA
    • Year and Date
      2012-11-09
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] P-28 Filaggrin (FLG) 遺伝子の変異と日本人食物アレルギー患者における関連解析2012

    • Author(s)
      広田朝光
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ゲノムワイド関連解析による成人気管支喘息発症に 関連する3つの新規ゲノム領域の同定2011

    • Author(s)
      広田朝光
    • Organizer
      日本人類遺伝学会 第56回大会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis2011

    • Author(s)
      Tomomitsu Hirota
    • Organizer
      American Society of Human Genetics (ASHG) Annual meeting 2011
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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