Identification of host cell factors relating the replication of respiratory syncytial virus

Research Project

Project/Area Number	23791205
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pediatrics
Research Institution	National Institute of Infectious Diseases
Principal Investigator	SHIRATO Kazuya 国立感染症研究所, ウイルス第3部, 主任研究官 (40415477)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	RSV / MDCK / ウイルス複製
Research Abstract	Respiratory syncytial virus (RSV) is a major causative agent of respiratory tract infections in children worldwide. Preterm children are at a particularly high risk of developing severe and lethal RSV infections. Because effective vaccines are not available, it is urgently necessary to develop antivirus drugs like oseltamivir for influenzavirus. In this study, we tried to identify host cell factors relating the replication of RSV using low-susceptible cell line, MDCK, and cDNA library derived from susceptible cells. As the results, expression of Ephrin-B2, RARRES2, and CCL2 increased the replication of RSV in MDCK. In future, it is necessary to clarify precise roles of these molecules in the replication of RSV.

Report

(4 results)