Identification of new biomarkers for the prediction of disease onset and for therapy evaluation in preterm infants with bronchopulmonary dysplasia
| Project/Area Number |
23791219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 未熟児医学 / 慢性肺疾患 / 酸化ストレス / カルボキシヘモグロビン / メトヘモグロビン |
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| Research Abstract |
Here, we examined levels of carboxyhemoglobin (CO-Hb) and methemoglobin (Met-Hb), markers of CO production and NO production, respectively, and discuss the usefulness of these markers to predict bronchopulmonary dysplasia (BPD) in preterm infants. CO-Hb levels in infants with moderate/severe BPD on postnatal days 5-7 were significantly higher than those in infants with no/mild BPD. Levels of urinary oxidative stress markers, i.e., advanced oxidative protein product (AOPP) and 8-hydroxydeoxyguanosine (8-OHdG), in infants with moderate/severe BPD also tended to be higher than those in infants with no/mild BPD on postnatal days 5-7. Thus, our data suggest that high levels of CO-Hb during the early neonatal period may reflect induction of hemeoxygenase-1 (HO-1) by oxidative stress and that CO-Hb levels are useful for early prediction of moderate/severe BPD in preterm infants.
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Report
(3 results)
Research Products
(5 results)
