Developing a novel therapy with bone marrow mononuclear cells for perinatal brain injuries
| Project/Area Number |
23791220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
SATO YOSHIAKI 名古屋大学, 医学部附属病院, 講師 (30435862)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 周産期脳障害 / 骨髄単核球 / 低酸素性虚血性脳症 / 周産期低酸素性虚血性脳症 / 骨髄間葉系幹細胞 / 幹細胞 |
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| Research Abstract |
It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we have performed basic experiments to develop a novel therapy with bone marrow mononuclear cells (BM-MNC), which is most ideal source of stem cells for the treatment against perinatal brain injuries. We evaluated the effect of administration of BM-MNC on perinatal HIE rat. We injected BM-MNC intravenously after hypoxic-ischemic insult. The injected BM-MNC was detected in the lung less than when we administered bone marrow mesenchymal stem cells. BM-MNC administration exerted anti-apoptotic effect, and tended to ameliorate learning impairment induced by HIE.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke.2014
Author(s)
Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T.
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Journal Title
Neuroscience
Volume: 263
Pages: 148-158
DOI
Related Report
Peer Reviewed
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[Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice2013
Author(s)
D Ibi, I Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, U. C. Lange, D. J. Adams, M. Azim Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima and K Yamada
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Journal Title
Glia
Volume: 61
Issue: 5
Pages: 679-693
DOI
Related Report
Peer Reviewed
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[Presentation] Administration of human umbilical cord blood cells reduce hypoxic-ischemic brain injury in the neonatal rat2013
Author(s)
T. Hattori, Y. Sato, T. Kondo, Y. Ichinohashi, S. Suzuki, M. Yamamoto, T. Kotani, H. Hirata, K. Nakanishi, M. Hayakawa
Organizer
Neuroscience 2013
Place of Presentation
San Diego, USA
Related Report
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[Presentation] 新生児低酸素性虚血性脳症モデルラットを用いた移植細胞体内動態の検討2013
Author(s)
近藤大貴, 佐藤義朗, 杉山裕一朗, 見松はるか, 伊藤美春, 齊藤明子, 服部哲夫, 藤巻英彦, 一ノ橋祐子, 中西圭子, 早川昌弘
Organizer
第49回日本周産期・新生児医学会学術集会
Place of Presentation
横浜市パシフィコ横浜
Related Report
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