The new criteria for transfusion to infant with anemia of prematurity based on the cerebral hemodynamics.

• Project/Area Number: 23791228
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: KOYANO Kosuke 香川大学, 医学部附属病院, 助教 (20437685)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 未熟児貧血 / 近赤外光 / 脳血液量 / 脳内酸素飽和度 / 輸血 / NIRS / 新生仔

Research Abstract

This study shows that transfusion decreases cerebral blood volume and increases cerebral oxygen saturation in infants with anemia of prematurity. In particular, changes in cerebral blood volume are greater when the hemogrobin level is low before transfusion. The use of time-resolved spectroscopy provides a non-invasive approach. Our results suggest that the cerebral blood volume and cerebral oxygen saturation may be useful criteria for determining the need for transfusion in preterm infants.

Research Products

• [Journal Article] The effect of blood transfusion on cerebral hemodynamics in preterm infants (2013)
  • Author(s): Koyano K, Kusaka T, Nakamura S, Nakamura M, Konishi Y, Miki T, Ueno M, Yasuda S, Okada H, Nishida T, Isobe K, Itoh S.
  • Journal Title: Transfusion Volume: 53(7) Pages: 1459-67
• [Journal Article] The effect of blood transfusion on cerebral hemodynamics in preterm infants (2012)
  • Author(s): Koyano K, Kusaka T, Nakamura S, Nakamura M, Konishi Y, Miki T, Ueno M, Yasuda S, Okada H, Nishida T, Isobe K, Itoh S.
  • Journal Title: The effect of blood transfusion on cerebral hemodynamics in preterm infants Volume: 現在不明 Issue: 7 Pages: 1459-1467
  • DOI: 10.1111/j.1537-2995.2012.03953.x
  • Peer Reviewed
• [Presentation] 新生児頭部における光学特性(吸光係数及び散乱係数)の血中ヘモグロビン濃度変化による影響について (2013)
  • Author(s): Kosuke Koyano
  • Organizer: 医用近赤研究会2013
• [Presentation] 「The impact of blood transfusion on cerebral hemodynamics and oxygenation in anemic preterm infnants.」「Cerebral Blood Volume in Anemic Piglets using Near-infrared Time-resolved Spectroscopy.」 (2012)
  • Author(s): Kosuke Koyano
  • Organizer: ASPR 2012
• [Presentation] The impact of blood transfusion on cerebral hemodynamics and oxygenation in anemic preterm infnants (2012)
  • Author(s): K. Koyano, W. Jinnai, S. Nakamura, M. Nakamura, S. Yasuda, T. Kusaka, K. Isobe, S. Itoh
  • Organizer: The 8th Congress of Asian Society for Pediatric Research
  • Place of Presentation: Seoul, Korea
• [Presentation] The effect of blood transfusion on cerebral hemodynamics in preterm infants (2012)
  • Author(s): Kosuke Koyano, Takashi Kusaka, Shinji Nakamura, Makoto Nakamura, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Saneyuki Yasuda, Hitoshi Okada, Tomoko Nishida, Kenichi Isobe, Susumu Itoh
  • Organizer: The 7th International Conference on Brain Monitoring and Neuroprotection in the Newborn
  • Place of Presentation: Tampa, FL, USA
• [Presentation] 未熟児貧血に対する輸血療法時における、脳血液量、脳内酸素飽和度の変化について (2012)
  • Author(s): 小谷野 耕佑
  • Organizer: 第7回香川県脳神経研究会
  • Place of Presentation: 香川県高松市
• [Presentation] The impact of blood transfusion on cerebral hemodynamics and oxygenation in anemic preterm infnants.」「Cerebral Blood Volume in Anemic Piglets using Near-infrared Time-resolved Spectroscopy (2011)
  • Author(s): Kosuke Koyano
  • Organizer: Brain 2011
• [Presentation] Cerebral Blood Volume in Anemic Piglets using Near-infrared Time-resolved Spectroscopy (2011)
  • Author(s): 小谷野 耕佑
  • Organizer: Brain 2011
  • Place of Presentation: スペイン バルセロナ
• [Presentation] The impact of blood transfusion on cerebral hemodynamics and oxygenation in anemic preterm infnants (2011)
  • Author(s): 小谷野 耕佑
  • Organizer: Brain 2011
  • Place of Presentation: スペイン バルセロナ
• [Presentation] 近赤外線時間分解分光装置（TRS）を用いて測定した未熟児貧血における輸血療法時の脳血液量、脳内ヘモグロビン酸素飽和度の変化について (2011)
  • Author(s): 小谷野 耕佑
  • Organizer: 第18回医用近赤外線分光法研究会
  • Place of Presentation: 岐阜県岐阜市
• [Presentation] 未熟児貧血における輸血療法時の脳血液量、脳内ヘモグロビン酸素飽和度の変化について (2011)
  • Author(s): 小谷野 耕佑
  • Organizer: 第56回未熟児新生児学会
  • Place of Presentation: 東京都
• [Presentation] 新生児頭部における光学特性（吸光係数及び散乱係数）の血中ヘモグロビン濃度変化による影響について
  • Author(s): 小谷野 耕佑、 中村 信嗣、 安田 真之、 日下 隆、 磯部 健一、 伊藤 進
  • Organizer: 第19 回医用近赤外線分光法研究会
  • Place of Presentation: 東京