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Stem cell therapy for neonatal hypoxia-ischemia

Research Project

Project/Area Number 23791229
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionEhime University

Principal Investigator

ZHU Pengxiang  愛媛大学, 医学(系)研究科(研究院), 助教 (40380216)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords新生児医学 / 脳性麻痺 / 再生医学 / 胚性幹細胞 / 神経前駆細胞 / ES細胞 / 再生療法 / ES細胞
Research Abstract

Neonatal hypoxic-ischemic insult is one of the most significant cause of pediatric encephalopathy and spastic cerebral palsy. Although the developing brain's plasticity allows for remarkable self-repair, severe disruption of normal myelination and cortical development upon neonatal brain injury are likely to generate life-persisting sensory-motor and cognitive deficits in the growing child. Currently, no treatments are available that can address the long-term consequences. Thus, regenerative medicine appears as a promising avenue to help restore normal developmental processes in affected infants. Here we have demonstrated that neural stem cells derived from embryonic stem cells have shown protective effects on hypoxic-ischemic insults. Our results have suggested that stem cell therapy has proven effective in promoting functional recovery in animal models of neonatal hypoxic-ischemic injury and therefore represents a hopeful therapy for this unmet medical condition.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells2012

    • Author(s)
      Zhu P, Hata R, Ogasawara M, Cao F, Kameda K, Yamauchi K, Schinkel AH, Maeyama K, Sakanaka M.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 32 Pages: 1897-908

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells.2012

    • Author(s)
      Zhu P, Hata R, Ogasawara M, Cao F, Kameda K, Yamauchi K, Schinkel AH, Maeyama K, Sakanaka M.
    • Journal Title

      J Cereb Blood Flow Metab.

      Volume: 32 Issue: 10 Pages: 1897-908

    • DOI

      10.1038/jcbfm.2012.92

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats2011

    • Author(s)
      Taguchi A, Zhu P, Cao F, Kikuchi-Taura A, Kasahara Y, Stern DM, Soma T, Matsuyama T and Hata R.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 31 Pages: 855-67

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats2011

    • Author(s)
      Taguchi A, Zhu P, Cao F, Kikuchi-Taura A, Kasahara Y, Stern DM, Soma T, Matsuyama T and Hata R.
    • Journal Title

      J Cereb Blood Flow Metab.

      Volume: 31 Pages: 855-67

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Intravenous infusion of dihydroginsenoside Rb1 ameliorates ischemia brain damage through up-regulation of Bcl-xL and VEGF.2012

    • Author(s)
      Pengxiang Zhu, Kimihiko Nakata, Masahiro Sakanaka.
    • Organizer
      The third Asis-Oceanian conference of Physical and Rehabilitation medicine in conjunction with the XI scientific meeting of the indonesian physical medicine and rehabilitation association.
    • Place of Presentation
      Bali Nusa Dua convention Center, Indonesia
    • Related Report
      2012 Research-status Report
  • [Presentation] Treatment of acute spinal cord injury with intravenous infusion of a ginseng saponin, ginsenoside Rb1.2012

    • Author(s)
      Kimihiko Nakata, Pengxiang Zhu, Masahiro Sakanaka.
    • Organizer
      The third Asis-Oceanian conference of Physical and Rehabilitation medicine in conjunction with the XI scientific meeting of the indonesian physical medicine and rehabilitation association.
    • Place of Presentation
      Bali Nusa Dua convention Center, Indonesia
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/data/course/list_detail.php?id=201100000037

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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