Project/Area Number |
23791232
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Embryonic/Neonatal medicine
|
Research Institution | Fukushima Medical University |
Principal Investigator |
OGASAWARA Kei 福島県立医科大学, 医学部, 助手 (00510348)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 一塩基多型 / グルココルチコイド受容体 / BclI多型 / 難治性低血圧 / ステロイドホルモン / SNP / 急性期難治性低血圧 / LC-MS/MS / LCMS/MS |
Research Abstract |
We enrolled preterm infants (n = 41) born at two hospitals in Fukushima. Four glucocorticoid receptors (GR) gene polymorphisms were analyzed by TaqMan SNP genotyping assay; their effects on clinical outcomes during hospitalization were evaluated retrospectively. The primary clinical outcomes were the presence of refractory hypotension, the maximum dose of dopamine (DOA) and dobutamine (DOB), the total hydrocortisone dose used in the first 48 h of life, and severe bronchopulmonary dysplasia. Among the four GR polymorphisms, only the BclI polymorphism was detected, with a genotype distribution of 33 G/G, 8 G/C, and 0 C/C. The following were significantly different between the G/G and G/C genotypes of BclI: refractory hypotension, DOA dose and DOB dose. This study indicates an association between BclI genotypes and refractory hypotension incidence in premature infants.
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