Oxygen promoted bFGF-induced Intimal Thickening
| Project/Area Number |
23791233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 動脈管 / bFGF / 動脈管開存症 / BFGF / インドメタシン / 胎児新生児医学 |
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| Research Abstract |
Postnatal patent ductus arteriosus (DA) is a major cause of morbidity and mortality in premature infants. The DA contracts immediately after birth in response to acute oxygenation and the withdrawal of placental prostaglandin. For complete closure, however, the DA region must also undergo intimal thickenings. It remains unknown how intimal thickening of the DA proceeds after birth. Here, we show that oxygenation induces basic fibroblast growth factor (bFGF) production in the DA in vivo. bFGF induced intimal thickening, leading to anatomical closure of the DA. bFGF with a low dose of cyclooxygenase inhibitor achieved the closure of preterm DA. Accordingly, oxygenation, in addition to inducing contraction, plays an important role in completing DA closure after prostaglandin removal. The current vasoconstrictor therapy may thus be combined with an inducer of postnatal intimal thickening, such as bFGF, to achieve permanent DA closure, especially in premature infants.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation2012
Author(s)
Yokoyama U, Ishiwata R, Jin MH, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y
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Journal Title
PLoS One
Volume: 7(5):e36724
Related Report
Peer Reviewed
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[Journal Article] Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation2012
Author(s)
Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida S, Yatsu K, Toya Y, Yasuda G, Kohara K, Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, Umemura S
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Journal Title
Hypertension
Volume: 59(4)
Pages: 854-60
Related Report
Peer Reviewed
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[Journal Article] Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight2012
Author(s)
Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S
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Journal Title
J Pharmacol Sci
Volume: 119(4)
Pages: 381-9
NAID
Related Report
Peer Reviewed
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