Genetic analysis of patent ductus arteriosus in preterm infants.

• Project/Area Number: 23791234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Nagoya City University
• Principal Investigator: SUGIURA Tokio 名古屋市立大学, 医学(系)研究科(研究院), 助教 (10381881)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 動脈管開存症 / 遺伝子多型 / インドメタイン / 早産児 / インドメタシン

Research Abstract

Patent ductus arteriosus is a common morbidity associated with preterm birth. Our major goal was to determine if genetic risk factors play a role in patient ductus arteriosus seen in preterm infants. DNA samples collected from 80 infants with a gestational age less than 32 weeks. There were 41 boys and 39 girls. Mean gestational age was 29 weeks (22-31 weeks), mean birth weight was 1059g (476-2158g). Natural close of ductus arteriosus was seen in 30% in infants, indomethacin with one time was used in 46% in infants, and indomethacin with two times were used in 23% in infants. Surgical closure of ductus arteriosus was proceeded in 7% in infants. We investigated single nucleotide polymorphism in transcription factor AP-2 by real time polymerase chain reaction.

Research Products

• [Journal Article] Viral load before and after exchange transfusion in a neonate with hyperbilirubinemia and congenital cytomegalovirus infection (2014)
  • Author(s): Ohashi K, Ito K, Endo T, Sugiura T, Awaya R, Goto T, Nagaya Y, Ueda H, Nagasaki R, Kato T, Saitoh S.
  • Journal Title: J Clin Case Rep Volume: 4 Issue: 03 Pages: 1-2
  • DOI: 10.4172/2165-7920.1000343
  • Peer Reviewed / Open Access
• [Journal Article] 先天性複合型下垂体機能低下症に伴う胆汁うっ滞の検討 (2014)
  • Author(s): 芦刈友加、伊藤孝一、杉浦時雄、遠藤剛、加藤晋、石田敦士、垣田博樹、今峰浩貴、長崎理香、水野晴夫、伊藤哲哉、加藤稲子、鈴木悟、戸苅創
  • Journal Title: 日本小児科学会雑誌 Volume: 118巻 Pages: 653-660
  • NAID: 40020067748
  • Peer Reviewed
• [Journal Article] Recurrent cholangitis with congenital hepatic fibrosis and pancreaticobiliary maljunction after Roux-en-Y reconstruction. (2013)
  • Author(s): Sugiura T, Endo T, Ito K, Goto K, Sato Y, Kondo S, Suzuki T, Hashimoto T.
  • Journal Title: Eur J Pediatr Surg Rep. Volume: 1 Issue: 01 Pages: 43-45
  • DOI: 10.1055/s-0033-1341420
  • Peer Reviewed
• [Journal Article] Massive intracranial hemorrhage caused by neonatal alloimmune thrombocytopenia associated with anti-group A antibody. (2013)
  • Author(s): Kato S, Sugiura T, Ueda H, Ito K, Kakita H, Kato I, Kawabata K, Ohto H, Togari H.
  • Journal Title: J Perinatol. Volume: 33 Issue: 1 Pages: 79-82
  • DOI: 10.1038/jp.2011.204
  • Peer Reviewed
• [Journal Article] Combination of Miller-Dieker syndrome and VACTERL association causes extremely severe clinical presentation. (2013)
  • Author(s): Ueda H, Sugiura T, Takeshita S, Ito K, Kakita H, Nagasaki R, Kurosawa K, Saitoh S.
  • Journal Title: Eur J Pediatr. Volume: 8 Issue: 11 Pages: 1-4
  • DOI: 10.1007/s00431-013-2099-z
  • Peer Reviewed
• [Journal Article] 脳瘤と多彩な大脳皮質形成異常を伴った羊膜索症候群の1例. (2013)
  • Author(s): 粟屋梨沙、伊藤孝一、上田博子、後藤盾信、垣田博樹、長崎理香、鈴森伸宏、加藤稲子、杉浦時雄、齋藤伸治
  • Journal Title: 日本周産期新生児医学会雑誌 Volume: 49巻 Pages: 1055-1059
  • NAID: 10031195020
  • Peer Reviewed
• [Journal Article] 急速に進行する肝転移に対して緊急放射線療法が奏功した神経芽腫4S期の1例 (2013)
  • Author(s): 鈴木敦詞、亀井美智、伊藤孝一、遠藤剛、杉浦時雄、齋藤伸治、佐藤陽子、近藤知史、高木大輔、鈴木達也、石倉聡、立川琴羽、伊藤康彦
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 50巻 Pages: 130-134
  • Peer Reviewed
• [Journal Article] 脳室周囲高エコー域と脳室周囲白質軟化症(PVEとPVL) (2013)
  • Author(s): 杉浦時雄
  • Volume: 43巻
  • Pages: 364-368
• [Journal Article] 脳瘤と多彩な大脳皮質形成異常を伴った羊膜索症候群の1例 (2013)
  • Author(s): 粟屋梨沙、伊藤孝一、上田博子、後藤盾信、垣田博樹、長崎理香、鈴森伸宏、加藤稲子、 杉浦時雄、齋藤伸治
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 49 Pages: 1055-1059
  • NAID: 10031195020
• [Journal Article] 脳室周囲高エコー域と脳室周囲白質軟化症(PVEとPVL) (2013)
  • Author(s): 杉浦時雄
  • Journal Title: 周産期医学 Volume: 43 Pages: 364-368
• [Journal Article] Periventricular leukomalacia is decreasing in Japan. (2012)
  • Author(s): Sugiura T, Goto T, Ueda H, Ito K, Kakita H, Nagasaki R, Mizuno K, Suzuki S, Kato I, Togari H.
  • Journal Title: Pediatr Nrurol. Volume: 47 Issue: 1 Pages: 35-39
  • DOI: 10.1016/j.pediatrneurol.2012.04.015
  • Peer Reviewed
• [Journal Article] Effects of exchange transfusion on cytokine profiles in necrotizing enterocolitis. (2012)
  • Author(s): Sugiura T, Kouwaki M, Goto K, Endo T, Koyama N, Togari H.
  • Journal Title: Pediatr Int. Volume: 54 Issue: 6 Pages: 931-933
  • DOI: 10.1111/j.1442-200x.2012.03654.x
  • Peer Reviewed
• [Journal Article] Hepatitis C virus clearance after discontinuation of pegylated interferon alpha-2a monotherapy in a child. (2012)
  • Author(s): Endo T, Ito K, Sugiura T, Goto K.
  • Journal Title: Case Rep Med. Volume: - Pages: 597348-597348
  • DOI: 10.1155/2012/597348
  • Peer Reviewed
• [Journal Article] Hypothermia attenuates the severity of oxidative stress development in asphyxiated newborns. (2012)
  • Author(s): Kakita H, Hussein MH, Kato S, Yamada Y, Nagaya Y, Asai H, Goto T, Ito K, Sugiura T, Daoud GA, Ito T, Kato I, Togari H.
  • Journal Title: J Crit Care. Volume: 27 Issue: 5 Pages: 469-473
  • DOI: 10.1016/j.jcrc.2011.12.013
  • Peer Reviewed
• [Journal Article] 高ウイルス量妊婦へのラミブジン投与によるB型肝炎ウイルス母子感染予防 (2012)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、鈴森伸宏、齋藤伸治、田中靖人
  • Journal Title: 肝臓 Volume: 53巻 Pages: 610-614
  • NAID: 10031120963
  • Peer Reviewed
• [Journal Article] エリスロポエチンと虚血性脳障害 (2012)
  • Author(s): 杉浦時雄
  • Journal Title: 周産期医学 Volume: 42巻 Pages: 563-566
• [Journal Article] 原発性硬化性胆管炎 (2012)
  • Author(s): 遠藤剛、杉浦時雄
  • Journal Title: 小児内科 Volume: 44巻 Pages: 428-429
• [Journal Article] 高ウイルス量妊婦へのラミブジン投与によるB 型肝炎ウイルス母子感染予防 (2012)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、鈴森伸宏、齋藤伸治、田中靖人
  • Journal Title: 肝臓 Volume: 53 Pages: 610-614
  • NAID: 10031120963
  • Peer Reviewed
• [Journal Article] エリスロポエチン療法 (2012)
  • Author(s): 杉浦時雄、西尾貴子
  • Journal Title: Neonatal Care Volume: 25 Pages: 168-171
• [Journal Article] Neurodevelopmental outcomes at 18 months' corrected age of infants born at 22 weeks of gestation (2011)
  • Author(s): Sugiura T, Kouwaki M, Togawa Y, Sugimoto M, Togawa T, Koyama N.
  • Journal Title: Neonatology Volume: 100 Issue: 3 Pages: 228-232
  • DOI: 10.1159/000324715
  • Peer Reviewed
• [Journal Article] Working Group for the Study of Pegylated Monotherapy for Children with Chronic Hepatitis C in the Japan Society of Pediatric Hepatology. Efficacy of pegylated interferon-α2a monotherapy in Japanese children with chronic hepatitis C (2011)
  • Author(s): Tsunoda T, Inui A, Etani Y, Kiyohara Y, Sugiura T, Ito K, Miyazawa R, Nagata I, Ida S, Fujisawa T.
  • Journal Title: Hepatol Res Volume: 41 Issue: 5 Pages: 399-404
  • DOI: 10.1111/j.1872-034x.2011.00789.x
  • Peer Reviewed
• [Journal Article] 戸苅創胎児期より経過観察しコイル塞栓術を施行した硬膜静脈洞奇形の1例 (2011)
  • Author(s): 佐藤恵美、加藤晋、熊崎滋、長屋嘉顕、伊藤孝一、垣田博樹、杉浦時雄、長崎理香、犬飼幸子、加藤稲子
  • Journal Title: 日本小児科学会雑誌 Volume: 115巻 Pages: 1566-1572
  • Peer Reviewed
• [Journal Article] 戸苅創胎内診断した、14番染色体父性片親ダイソミーの1例 (2011)
  • Author(s): 上田博子、杉浦時雄、伊藤孝一、佐々木智章、加藤晋、鈴森伸宏、鈴木悟、加藤稲子
  • Journal Title: 日本周産期新生児医学会雑誌 Volume: 47巻 Pages: 54-59
  • Peer Reviewed
• [Journal Article] 遺伝性肝内胆汁うっ滞の病態 (2011)
  • Author(s): 杉浦時雄
  • Journal Title: 小児内科 Volume: 43巻 Pages: 1034-1037
• [Journal Article] ウイルスの母子感染HBV,HCVを中心に (2011)
  • Author(s): 杉浦時雄、後藤健之
  • Journal Title: 産婦人科治療 Volume: 102巻 Pages: 123-129
• [Journal Article] Neurodevelopmental outcomes at 18 months' corrected age of infants born at 22 weeks of gestation. (2011)
  • Author(s): Sugiura T, Kouwaki M, Togawa Y, Sugimoto M, Togawa T, Koyama N.
  • Journal Title: Neonatology. Volume: 100 Pages: 228-232
  • Peer Reviewed
• [Journal Article] ウイルスの母子感染 HBV、HCVを中心に (2011)
  • Author(s): 杉浦時雄、後藤健之
  • Journal Title: 産婦人科治療 Volume: 102 Pages: 123-129
• [Presentation] 小児胆汁うっ滞疾患に対する次世代高速シーケンサーを用いた網羅的遺伝子解析 (2013)
  • Author(s): 戸川貴夫、伊藤孝一、遠藤剛、杉浦時雄、齋藤伸治
  • Organizer: 第58回日本未熟児新生児学会
  • Place of Presentation: 金沢
  • Year and Date: 2013-12-02
• [Presentation] 当院における13trisomy児の臨床像と医療的介入について (2013)
  • Author(s): 田中元、上田博子、伊藤孝一、杉浦時雄、長崎理香、加藤丈典齋藤伸治
  • Organizer: 第58回日本未熟児新生児学会
  • Place of Presentation: 金沢
  • Year and Date: 2013-12-01
• [Presentation] X連鎖性遺伝性水頭症への出生前からのカウンセリング (2013)
  • Author(s): 佐藤新紀子、上田博子、伊藤孝一、杉浦時雄、加藤丈典、長崎理香、齋藤伸治
  • Organizer: 第58回日本未熟児新生児学会
  • Place of Presentation: 金沢
  • Year and Date: 2013-11-30
• [Presentation] 先天性心疾患術後の乳糜胸に対しトルバプタンが有効であった1例 (2013)
  • Author(s): 佐藤新紀子、上田博子、鈴木一孝、伊藤孝一、杉浦時雄、加藤丈典、長崎理香、犬飼幸子、齋藤伸治
  • Organizer: 第22回東海新生児研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2013-11-16
• [Presentation] 当院NICUにおける剖検およびAiの実施実績 (2013)
  • Author(s): 吉田悟、佐藤新紀子、上田博子、後藤盾信、伊藤孝一、杉浦時雄、長崎理香、加藤丈典、斎藤伸治
  • Organizer: 第49回日本周産期・新生児医学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-07-16
• [Presentation] 愛知県におけるHTLV-1母子感染の実態 (2013)
  • Author(s): 杉浦時雄、上田博子、伊藤孝一、長崎理香、加藤丈典、鈴木正利、齋藤伸治
  • Organizer: 第49回日本周産期・新生児医学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-07-16
• [Presentation] Miller-Dieker syndromeとVATER連合の合併例 (2013)
  • Author(s): 上田博子、竹下覚、後藤盾信、伊藤孝一、長崎理香、垣田博樹、杉浦時雄、齋藤伸治
  • Organizer: 第49回日本周産期・新生児医学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-07-16
• [Presentation] 高ウイルス量妊婦へのラミブジン投与によるB型肝炎ウイルス母子感染予防 (2013)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、齋藤伸治、鈴森伸宏、高野智子、田尻仁、齋藤伸治、田中靖人
  • Organizer: 第30回日本小児肝臓研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2013-07-13
• [Presentation] 先天性肝線維症・膵胆管合流異常症に対し胆道再建術後、逆行性胆管炎を繰り返した1例 (2013)
  • Author(s): 佐藤新紀子、杉浦時雄、遠藤剛、伊藤孝一、齋藤伸治
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2013-04-20
• [Presentation] 内頚動脈欠損を伴ったアラジール症候群の1例 (2013)
  • Author(s): 遠藤剛、根岸豊、伊藤孝一、服部文子、杉浦時雄、安藤直樹、齋藤伸治
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2013-04-20
• [Presentation] 胎児期より腹部嚢胞を指摘されていた先天性胆管拡張症の一例 (2013)
  • Author(s): 上田佳朋、櫻井典子、大橋圭、上田博子、伊藤孝一、長崎理香、加藤丈典、杉浦時雄、高木大輔、近藤知史、斎藤伸治
  • Organizer: 第16回中部出生前医療研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2013-03-02
• [Presentation] Combination of Miller-Dieker syndrome and VATER association causes extremely severe clinical presentation (2013)
  • Author(s): Nikiko Sato, Hiroko Ueda, Tokio Sugiura, Satoru Takeshita, Koichi Ito, Hiroki Kakita, Rika Nagasaki, Kenji Kurosawa, Shinji Saitoh
  • Organizer: 11th World Congress of Perinatal Medicine
  • Place of Presentation: Moscow, Russia
• [Presentation] Exchange transfusion was not effective to reduce viral load in congenital cytomegalovirus infection (2013)
  • Author(s): Kei Ohashi, Koichi Ito, Takeshi Endo, Tokio Sugiura, Risa Away, Tatenobu Goto, Hiroko Ueda, Rika Nagasaki, Takenori Kato, Shinji Saitoh
  • Organizer: 11th World Congress of Perinatal Medicine
  • Place of Presentation: Moscow, Russia
• [Presentation] Lamivudine treatment during pregnancy to prevent mother-to-child transmission of hepatitis b virus infection in Japan (2013)
  • Author(s): Tokio Sugiura, Hitoshi Tajiri, Tomoko Takano, Kenji Goto, Takeshi Endo, Koichi Ito, Nobuhiro Suzumori, Yasuhito Tanaka
  • Organizer: 11th World Congress of Perinatal Medicine
  • Place of Presentation: Moscow, Russia
• [Presentation] A case of discordant congenital cytomegalovirus infection in twin (2013)
  • Author(s): Takeshi Endo, Koichi Ito, Tokio Sugiura
  • Organizer: 11th World Congress of Perinatal Medicine
  • Place of Presentation: Moscow, Russia
• [Presentation] Survival of fetuses with oligohydramnios (2013)
  • Author(s): Hajime Tanaka, Tatenobu Goto, Tokio Sugiura, Risa Awaya, Hiroko Ueda, Koichi Ito, Hiroki Kakita, Rika Nagasaki, Takenori Kato, Shinji Saitoh
  • Organizer: 11th World Congress of Perinatal Medicine
  • Place of Presentation: Moscow, Russia
• [Presentation] 愛知県におけるHTLV-1母子感染の実態 (2013)
  • Author(s): 杉浦時雄、上田博子、伊藤孝一、長崎理香、加藤丈典、鈴木正利、齋藤伸治
  • Organizer: 第49回日本周産期・新生児医学会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] 高ウイルス量妊婦へのラミブジン投与によるB 型肝炎ウイルス母子感染予防 (2013)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、齋藤伸治、鈴森伸宏、高野智子、田尻仁、齋藤伸治、田中靖人
  • Organizer: 第30回日本小児肝臓研究会
  • Place of Presentation: JA埼玉共済ビル（埼玉）
• [Presentation] Lamivudine treatment during pregnancy to prevent mother-to-child transmission of hepatitis b virus infection in Japan. (2013)
  • Author(s): Tokio Sugiura, Hitoshi Tajiri, Tomoko Takano, Kenji Goto, Takeshi Endo, Koichi Ito, Nobuhiro Suzumori, Yasuhito Tanaka
  • Organizer: 11th World Congress of Perinatal Medicine
  • Place of Presentation: Crocus Expo Congress Centre(Moscow, Russia)
• [Presentation] 先天性サイトメガロウイルス感染症における交換輸血前後のウイルス量の変化 (2012)
  • Author(s): 大橋圭、伊藤孝一、遠藤剛、杉浦時雄、上田博子、加藤丈典、長崎理香、齋藤伸治
  • Organizer: 第57回日本未熟児新生児学会
  • Place of Presentation: 熊本
  • Year and Date: 2012-11-26
• [Presentation] 小児C型慢性肝炎に対するPEG-IFN単独療法の治療成績 (2012)
  • Author(s): 伊藤孝一、遠藤剛、杉浦時雄、安藤直樹、吉田成美、水野寛太郎、齋藤伸治
  • Organizer: 第39回日本小児栄養消化器肝臓学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-14
• [Presentation] 新生児・乳児胆汁うっ滞の検討 (2012)
  • Author(s): 粟屋梨沙、遠藤剛、伊藤孝一、杉浦時雄、齋藤伸治
  • Organizer: 第29回日本小児肝臓研究会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-13
• [Presentation] HBV母子感染予防目的でラミブジン投与した1妊婦例 (2012)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、鈴森伸宏、齋藤伸治
  • Organizer: 第48回日本周産期・新生児医学会
  • Place of Presentation: 大宮
  • Year and Date: 2012-07-10
• [Presentation] 羊水過少シークエンス17例の検討 (2012)
  • Author(s): 後藤盾信、粟屋梨沙、上田博子、伊藤孝一、垣田博樹、杉浦時雄、長崎理香、齋藤伸治
  • Organizer: 第48回日本周産期・新生児医学会
  • Place of Presentation: 大宮
  • Year and Date: 2012-07-10
• [Presentation] 頭蓋内出血を起した抗A抗体による新生児同種血小板減少症(NAIT)の一例 (2012)
  • Author(s): 上田博子、杉浦時雄、伊藤孝一、垣田博樹、後藤盾信、加藤晋、齋藤伸治
  • Organizer: 第48回日本周産期・新生児医学会
  • Place of Presentation: 大宮
  • Year and Date: 2012-07-10
• [Presentation] 先天性心疾患を合併した超低出生体重児に対し心臓外科手術を行った3例 (2012)
  • Author(s): 佐藤新紀子、上田博子、後藤盾信、鈴木一孝、伊藤孝一、垣田博樹、杉浦時雄、長崎理香、犬飼幸子、齋藤伸治
  • Organizer: 第48回日本周産期・新生児医学会
  • Place of Presentation: 大宮
  • Year and Date: 2012-07-10
• [Presentation] HBV母子感染ハイリスク妊婦へのラミブジン投与 (2012)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、田中靖人
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2012-06-08
• [Presentation] LIS1を含まない17p13.3微細欠失によるMiller-Dieker症候群の1例 (2012)
  • Author(s): 上田博子、後藤盾信、伊藤孝一、垣田博樹、杉浦時雄、長崎理香、加藤稲子、齋藤伸治、竹下覚、黒澤健司
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-20
• [Presentation] 双胎の一例のみに胎内感染が成立した先天性サイトメガロウイルス感染症例 (2012)
  • Author(s): 遠藤剛、伊藤孝一、杉浦時雄、服部文子、齋藤伸治
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-20
• [Presentation] 腸重積症に対して、delayed repeat enemaを行い整復可能であった1例 (2012)
  • Author(s): 上田博子、伊藤孝一、遠藤剛、杉浦時雄、齋藤伸治、高木大輔、近藤知史、佐藤陽子、平林靖高
  • Organizer: 第254回日本小児科学会東海地方会
  • Place of Presentation: 津
  • Year and Date: 2012-01-29
• [Presentation] Genetic analysis of benign recurrent intrahepatic cholestasis (2012)
  • Author(s): Tokio Sugiura, Takeshi Endo, Koichi Ito, Kenji Goto
  • Organizer: 4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Recurrent cholangitis with congenital hepatic fibrosis after Roux-en-Y reconstruction (2012)
  • Author(s): Nikiko Sato, Tokio Sugiura, Takeshi Endo, Koichi Ito, Kenji Goto, Tatsuya Suzuki, Takashi Hashimoto
  • Organizer: 4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Mutations in the basal core promoter and precore regions of the hepatitis B virus in children (2012)
  • Author(s): Takeshi Endo, Koichi Ito, Tokio Sugiura
  • Organizer: 4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Efficacy of pegylated interferon-α2a monotherapy in Japanese children with chronic hepatitis C (2012)
  • Author(s): Koichi Ito, Takeshi Endo, Tokio Sugiura, Naoki Ando, Seibi Yoshida, Kantaro Mizuno, Shinji Saito
  • Organizer: 4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Lamivudine treatment during pregnancy to prevent mother-to-child transmission of hepatitis B virus infection. 4th World Congress of Pediatric Gastroenterology (2012)
  • Author(s): Mizuki Kobayashi, Tokio Sugiura, Kenji Goto, Takeshi Endo, Koichi Ito,Nobuhiro Suzumori, Yasuhito Tanaka
  • Organizer: Hepatology and Nutrition
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Rapidly progressive hepatomegaly in an infant with stage 4S neuroblastoma (2012)
  • Author(s): Atsushi Suzuki, Michi Kamei, Yasuhiko Ito, Kouichi Ito, Tsuyoshi Endo, Tokio Sugiura, Shinji Saitoh, Youko Sato, Satoshi Kondo, Daisuke Takagi, Tatuya Suzuki, Satoshi Ishikura
  • Organizer: 4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Genetic analysis of benign recurrent intrahepatic cholestasis. (2012)
  • Author(s): Tokio Sugiura, Takeshi Endo, Koichi Ito, Kenji Goto
  • Organizer: 4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Taipei, Taiwan
• [Presentation] PEG-IFN単独療法が有効でC型肝炎ウイルス関連糸球体腎炎の一女児例 (2011)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一
  • Organizer: 第39回日本肝臓学会西部会
  • Place of Presentation: 岡山
  • Year and Date: 2011-12-10
• [Presentation] 劇症肝炎の1乳児例 (2011)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、若月準
  • Organizer: 第72回名古屋市立大学小児科集談会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-09-17
• [Presentation] 脳室周囲白質軟化症の全国調査-PVLは減っている- (2011)
  • Author(s): 杉浦時雄、伊藤孝一、垣田博樹、水野恵介、鈴木悟、加藤稲子、戸苅創
  • Organizer: 第47回日本周産期・新生児医学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-11
• [Presentation] Neurodevelopmental outcomes at 18 months'corrected age of infants born at 22 weeks of gestation (2011)
  • Author(s): Tokio Sugiura, Masanori Kouwaki, Yasuko Togawa, Mari Sugimoto, Takao Togawa, Norihisa Koyama
  • Organizer: 10th World Congress of Perinatal Medicine
  • Place of Presentation: Punta del Este, Uruguay
• [Presentation] A case of systemic aplasia cutis congenita : a newly recognized syndrome? (2011)
  • Author(s): Yuki Obayashi, Tokio Sugiura, Masanori Kouwaki, Shusuke Kiyosaw, Yoshie Sasada, Matsuyoshi Maeda, Kenji Goto, Norihisa Koyama
  • Organizer: 10th World Congress of Perinatal Medicine
  • Place of Presentation: Punta del Este, Uruguay
• [Presentation] Massive intracranial hemorrhage caused by neonatal alloimmune thrombocytopenia associated with anti-group A antibody (2011)
  • Author(s): Kohei Aoyama, Shin Kato, Tokio Sugiura, Hiroko Ueda, Koichi Ito, Hiroki Kakita, Ineko Kato, Kinuyo Kawabata, Hitoshi Ohto, Hajime Togari
  • Organizer: 10th World Congress of Perinatal Medicine
  • Place of Presentation: Punta del Este, Uruguay
• [Presentation] Periventricular leukomalacia was decreasing in Japan (2011)
  • Author(s): Rika Nagasaki, Tokio Sugiura, Koichi Ito, Hiroki Kakita, Keisuke Mizuno, Satoshi Suzuki, Ineko Kato, Hajime Togari
  • Organizer: 10th World Congress of Perinatal Medicine
  • Place of Presentation: Punta del Este, Uruguay
• [Presentation] Cytokine profiles before, during, and after exchange transfusion in the preterm infant with necrotizing enterocolitis (2011)
  • Author(s): Satoru Takeshita, Tokio Sugiura, Masanori Kouwaki, Kenji Goto, Takeshi, Endo, Koichi Ito, Norihisa Koyama, Hajime Togari
  • Organizer: 10th World Congress of Perinatal Medicine
  • Place of Presentation: Punta del Este, Uruguay
• [Presentation] 脳室周囲白質軟化症の全国調査－PVLは減っている－ (2011)
  • Author(s): 杉浦時雄、伊藤孝一、垣田博樹、水野恵介、鈴木悟、加藤稲子、戸苅創
  • Organizer: 第47回 日本周産期・新生児医学会
  • Place of Presentation: 札幌コンベンションセンター（北海道）
• [Presentation] PEG-IFN単独療法が有効でC型肝炎ウイルス関連糸球体腎炎の一女児例 (2011)
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一
  • Organizer: 第39回日本肝臓学会西部会
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
• [Presentation] Neurodevelopmental outcomes at 18 months’ corrected age of infants born at 22 weeks of gestation. (2011)
  • Author(s): Sugiura T, Kouwaki M, Togawa Y, Sugimoto M, Togawa T, Koyama N.
  • Organizer: 10th World Congress of Perinatal Medicine
  • Place of Presentation: Punta del Este, Uruguay
• [Presentation] HBV母子感染ハイリスク妊婦へのラミブジン投与
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、田中靖人
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢（金沢）
• [Presentation] HBV母子感染予防目的でラミブジン投与した１妊婦例
  • Author(s): 杉浦時雄、遠藤剛、伊藤孝一、鈴森伸宏、齋藤伸治
  • Organizer: 第48回日本周産期・新生児医学会
  • Place of Presentation: 大宮ソニックシティ（大宮）