| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
Patent ductus arteriosus is a common morbidity associated with preterm birth. Our major goal was to determine if genetic risk factors play a role in patient ductus arteriosus seen in preterm infants. DNA samples collected from 80 infants with a gestational age less than 32 weeks. There were 41 boys and 39 girls. Mean gestational age was 29 weeks (22-31 weeks), mean birth weight was 1059g (476-2158g). Natural close of ductus arteriosus was seen in 30% in infants, indomethacin with one time was used in 46% in infants, and indomethacin with two times were used in 23% in infants. Surgical closure of ductus arteriosus was proceeded in 7% in infants. We investigated single nucleotide polymorphism in transcription factor AP-2 by real time polymerase chain reaction.
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