| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Low birth weight is related to increase incidence of psychopathologies later in life. Recent studies suggest that maternal malnutrition affects fetal programming of hypothalamic-pituitary-adrenal (HPA) axis although the mechanism is unknown. We demonstrated that low birth weight offspring (LBW) delivered from malnourished dams showed prolonged HPA axis activation compared with that of control offspring (NBW) and impaired downregulation of corticotropin-releasing hormone (CRH) receptor type 1 (CRHR1) in the anterior pituitary (AP) in immobilization. Immobilization increased expression of AP miR-449a, which has a sequences predicted to bind to the CRHR1 3'UTR in NBW, but not in LBW. Overexpression of miR-449a decreased CRHR1 expression and CRHR1 3'UTR activity in vitro. These results indicated that impairment of miR-449a expression causes the dysregulation of AP CRHR1 expression, resulting in prolonged HPA axis activation in stress in LBW.
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