Development of novel therapies for atopic dermatitis

Research Project

Project/Area Number	23791244
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	Hokkaido University
Principal Investigator	HAMASAKA Asuka 北海道大学, 大学院・医学研究科, 非常勤講師 (60598382)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	アトピー性皮膚炎 / モデルマウス / 新規治療法 / フィラグリン / 治療 / 遺伝子 / アレルギー・ぜんそく
Research Abstract	Flaky tail mice carry a 1bp deletion in a gene encoding filaggrin and develop spontaneous dermatitis. In this study, we used flaky tail mice as a model of atopic dermatitis. Improvement of dermatitis was observed after treatment with MIF-DNA vaccine or DHEMQ. These data suggest that both MIF-DNA vaccine and DHMEQ be a novel therapeutic option for atopic dermatitis.