| Project/Area Number |
23791247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
NAKAJIMA Koji 弘前大学, 医学(系)研究科(研究院), 助教 (70374832)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 表皮細胞 / 転写因子 / 分化 / 角化 / 増殖 |
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| Research Abstract |
Skn-1, a member of the POU domain protein family, appears to be expressed predominantly in epidermal keratinocytes and is thought to play a critical role in keratinocyte differentiation and proliferation. Since Transcription factors are translated in the cytoplasm and transferred to the nucleus, study of nuclear transfer mechanism of their transcription factors is important. Recently, some studies reported that nuclear transfer of transcription factor is regulated in tissue or cell specific manners. However, nuclear transfer of transcription factor Skn-1 has not elucidated yet. In this study, we examined the mechanisms involved in the nuclear localization of Skn-1a to clarify involvement of Skn-1 nuclear transfer in keratinocyte differentiation and proliferation. The results showed that Skn-1 nuclear transfer may be related with keratinocyte differentiation and proliferation.
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