Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Research Abstract |
We established SIRT6 transgenic mice. SIRT6, which plays important roles in DNA repair pathways, is overexpressed in epidermis of those TG mice. We irradiated UVB on the back of those TG mice, and analyzed acute and chronic skin damages. We demonstrated SIRT6 protein overexpression in epidermis inhibited UVB-induces acute erythema, and suppressed chronic skin damages.
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