Analyses of SIRT6 function in preventing ultraviolet B-induced skin damages
| Project/Area Number |
23791248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
ROKUNOHE Daiki 弘前大学, 医学(系)研究科(研究院), 助教 (50436036)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚炎症 / 再生学 / 寿命 / 紫外線皮膚障害 / 皮膚悪性腫瘍 / 紫外線障害 |
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| Research Abstract |
We established SIRT6 transgenic mice. SIRT6, which plays important roles in DNA repair pathways, is overexpressed in epidermis of those TG mice. We irradiated UVB on the back of those TG mice, and analyzed acute and chronic skin damages. We demonstrated SIRT6 protein overexpression in epidermis inhibited UVB-induces acute erythema, and suppressed chronic skin damages.
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Report
(3 results)
Research Products
(13 results)
