The effect of myeloid derived suppressor cells on the induction of peripheral tolerance
| Project/Area Number |
23791249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
FUJIMURA Taku 東北大学, 大学院・医学系研究科, 助教 (50396496)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 皮膚腫瘍学 / 皮膚腫瘍免疫 / 悪性黒色腫 / 抑制型マクロファージ / MDSC / 骨髄由来抑制細胞（MDSC) / マクロファージ / 制御性T細胞 / 免疫寛容 / 皮膚悪性腫瘍 |
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| Research Abstract |
We invstigated mainly mouse immunosuppressive macrophages and myeloid derived suppressor cells, as well as regulatory T cells on the induction of peripheral tolerance in cancer patient and cancer bearing mouse. By this project, we have published 8 English papers concerned about the effect of immunosuppressive macrophages on cancer microenvironment. Another 5 English papers are still under submission. Through this project, wecharacterized the further subtypes of immunosuppressive macrophages, and in future, by targeting these macrophages in cancer patients, further optimal therapy might be established.
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Report
(3 results)
Research Products
(26 results)
