Molecular bases of squamous cell carcinogenesis:regulation and failure of phosphatidyl inositol metabolism in epidermis
| Project/Area Number |
23791251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | St. Marianna University School of Medicine (2012)
Akita University (2011) |
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Principal Investigator |
KAWAMURA Nanami 聖マリアンナ医科大学, 医学部, 講師 (70323152)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 扁平上皮癌 / PI3K, PTEN / PTEN / PI3K |
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| Research Abstract |
In this grant program, we attempted to elucidate the biological roles of p110α isoform of phosphatidylinositol-3-kinase in squamous cell carcinogenesis. The transgenic mouse studies showed that the genetic defect of p110- gene cause embryonic lethality, which suggested that p110-may play important roles in the maintenance of keratinocyte stem cells. The further studies showed that the genetic defect of PTEN gene cause increased susceptibility to spontaneous and chemical carcinogenesis, which suggested that PTEN may play important roles in squamous cell carcinogenesis.
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Report
(3 results)
Research Products
(4 results)
