The role of the TWIST in Squamous cell carcinoma

• Project/Area Number: 23791259
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Kanazawa University
• Principal Investigator: ISHII Takayuki 金沢大学, 医学系, 協力研究員 (90420330)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 皮膚腫瘍学 / 有棘細胞癌 / TWIST / 上皮間葉移行

Research Abstract

We examined the relationship between cutaneous Squamous cell carcinoma(cSCC) and TWIST, Snail, E-cadherin and Human papilloma virus(HPV). TWIST, Snail were over expressed in invasive cSCCs. On the other hand E-cadherin expressed low level in invasive cSCCs. We could not find the relationship between cSCCs and HPV. In cSCC insitu, these expression levels were same with invasive cases. Cell membrenes of keratinocytes were also stained with E-cadherin.