Identification of novel immune-suppressive factors on melanoma cells

• Project/Area Number: 23791261
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: University of Yamanashi
• Principal Investigator: INOZUME Takashi 山梨大学, 医学部附属病院, 助教 (80334853)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 皮膚腫瘍学 / メラノーマ / 腫瘍免疫 / T cell抑制因子 / 国際情報交流

Research Abstract

Melanoma is an immunogenic tumor. On the other hands, it expressesmany unknown immnunosuppressive factors. In this research, we have identified some novelimmnunosuppressive factors expressed by melanoma cells, and revealed that inhibition forthem elicited anti-melanoma immune-response. Our findings may contribute to developingan effective treatment for melanoma.

Research Products

• [Presentation] CD155 is highly expressed bymelanoma tissues and it suppresses theactivation of melanoma specific CTLs viainteraction with TIGIT (2012)
  • Author(s): 猪爪隆史
  • Organizer: The 37thannual meeting of the Japanesesociety for investigative dermatology
  • Place of Presentation: ロワジールホテル那覇、沖縄
• [Presentation] CD155 はほぼすべてのメラノーマ細胞株に発現され、メラノーマ特異的 CTLの活性化を直接に抑制する (2012)
  • Author(s): 猪爪隆史
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: 北海道大学学術交流会館、北海道
• [Presentation] Enhanced NGFR signal inmelanoma cells suppresses the tumorrecognition by melanoma specific T cells. (2012)
  • Author(s): 猪爪隆史
  • Organizer: 2012 SID annual meeting and 75thanniversary celebration
  • Place of Presentation: Raleighconventional center, Raleigh, NorthCarolina, USA
• [Presentation] CD155はほぼすべてのメラノーマ細胞株に発現されメラノーマ特異的CTLの活性化を直接に抑制する (2012)
  • Author(s): 猪爪隆史
  • Organizer: 第１６回日本がん免疫学会総会
  • Place of Presentation: 北海道大学学術交流会館(北海道）
• [Presentation] CD155 is highly expressed by melanoma tissues and it suppresses the activation of melanoma specific CTLs via interaction with TIGIT (2012)
  • Author(s): Takashi Inozume
  • Organizer: The 37th annual meeting of the Japanese society for investigative dermatology
  • Place of Presentation: ロワジールホテル那覇(沖縄）
• [Presentation] Enhanced NGFR signal in melanoma cells suppresses the tumor recognition by melanoma specific T cells (2012)
  • Author(s): Takashi Inozume
  • Organizer: 2012 SID annual meeting and 75th anniversary celebration
  • Place of Presentation: Raleigh convention center (Raleigh)
• [Presentation] NGFR is up-regulated onmelanoma cells by IFNg stimulation and itsuppressed the tumor recognition by tumorspecific T cells (2011)
  • Author(s): 猪爪隆史
  • Organizer: The 36thannual meeting of the Japanesesociety for investigative dermatology
  • Place of Presentation: 京都国際会議場、京都
• [Presentation] NGFRはIFN-g刺激でメラノーマ細胞上に発現増強されメラノーマ特異的T細胞からの認識を抑制する
  • Author(s): 猪爪隆史
  • Organizer: 第１５回日本がん免疫学会総会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府）
• [Presentation] NGFRはIFN-g刺激でメラノーマ細胞上に発現増強されメラノーマ特異的T細胞からの認識を抑制する
  • Author(s): Takashi Inozume
  • Organizer: 第３６回日本研究皮膚科学会
  • Place of Presentation: 京都国際会議場（京都府）
• [Remarks] 山梨大学研究者総覧ページ
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_Index.Main?