Control of spindle orientation in skin basal cells by c-Abland possible role of calcium signaling in spindle orientation
Project/Area Number |
23791265
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 細胞分裂軸 / 皮膚基底細胞 / ABL1 / 分裂軸方向制御 / 皮膚 |
Research Abstract |
We performed a genome-scale RNA-mediated interference screen of human kinases using the HeLa cell system and identified ABL1 tyrosine kinase as a novel regulator for spindle orientation in mammalian cells. We find that ABL1 regulates spindle orientation not only in HeLa cells but also in mouse epidermis. Furthermore, we found that ABL1 regulates spindle orientation through LGN and NuMA, which form an evolutionarily conserved regulatory complex for spindle orientation.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] "ABL1 regulates spindle orientation in adherent cells and mammalian skin."2012
Author(s)
Matsumura, S., Hamasaki, M., Yamamoto, T., Ebisuya, M., Sato, M., Nishida, E., and *Toyoshima, F.
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Journal Title
Nat. Commun.
Volume: 3
Issue: 1
Pages: 626-626
DOI
Related Report
Peer Reviewed
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