serum microRNA levels in skin diseases
| Project/Area Number |
23791279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
JINNIN Masatoshi 熊本大学, 大学院・生命科学研究部, 講師 (60401048)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 皮膚 / microRNA / 強皮症 / マイクロRNA / 国際情報交流 |
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| Research Abstract |
In this project, we found that microRNA can be purified from serum by miRNeasy RNAisolation kit. We compared serum levels of various microRNAs between healthy controlsor disease controls and patients with scleroderma, psoriasis, melanoma, squamous cellcarcinoma, localized scleroderma or dermatomyositis. We also analyzed the correlationof serum microRNA levels and clinical/laboratory features in each disease. We suggesta possibility that serum microRNA levels can be useful markers for diagnosis or evaluatingdisease activities. Furthermore, we revealed that the intermittent overexpression oflet-7a in the mice skin by intraperitoneal injection attenuated the skin fibrosis inducedby bleomycin.
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Report
(3 results)
Research Products
(67 results)
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[Journal Article] TGF-β-Mediated Downregulation of MicroRNA-196a Contributes to the Constitutive Upregulated Type I Collagen Expression in Scleroderma Dermal Fibroblasts.2012
Author(s)
Honda N, Jinnin M, Kajihara I, Makino T, Makino K, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
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Journal Title
J Immunol
Volume: 188
Pages: 3323-3331
Related Report
Peer Reviewed
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[Journal Article] Angiopoietin-like protein 2 is animportant facilitator of inflammatorycarcinogenesis and metastasis2011
Author(s)
Aoi J, Endo M, Kadomatsu T, Miyata K,Nakano M, Horiguchi H, Ogata A, Odagiri H,Yano M, Araki K, Jinnin M, et al
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Journal Title
Cancer Res
Volume: 71巻
Pages: 7502-7512
Related Report
Peer Reviewed
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[Journal Article] The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker.2011
Author(s)
Kanemaru H, Fukushima S, Yamashita J, Honda N, Oyama R, Kakimoto A, Masuguchi S, Ishihara T, Inoue Y, Jinnin M, Ihn H.
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Journal Title
J Dermatol Sci
Volume: 61
Pages: 187-193
NAID
Related Report
Peer Reviewed
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[Journal Article] Circulating microRNA associated with TNF-α signaling pathway in patients with plaque psoriasis.2011
Author(s)
Oyama R, Jinnin M, Kakimoto A, Kanemaru H, Ichihara A, Fujisawa A, Honda N, Masuguchi S, Fukushima S, Maruo K, Ihn H.
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Journal Title
J Dermatol Sci
Volume: 61
Pages: 209-211
NAID
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Peer Reviewed
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[Presentation] TGF-β-Mediated Downregulation of MicroRNA-196a Contributes to the Constitutive Upregulated Type I Collagen Expression in Scleroderma Dermal Fibroblasts.
Author(s)
Honda N, Jinnin M, Kajihara I, Makino T, Makino K, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
Organizer
日本研究皮膚科学会
Place of Presentation
京都市左京区宝ヶ池 国立京都国際会館/ICC Kyoto
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