| Project/Area Number |
23791279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
JINNIN Masatoshi 熊本大学, 大学院・生命科学研究部, 講師 (60401048)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 皮膚 / microRNA / 強皮症 / マイクロRNA / 国際情報交流 |
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| Research Abstract |
In this project, we found that microRNA can be purified from serum by miRNeasy RNAisolation kit. We compared serum levels of various microRNAs between healthy controlsor disease controls and patients with scleroderma, psoriasis, melanoma, squamous cellcarcinoma, localized scleroderma or dermatomyositis. We also analyzed the correlationof serum microRNA levels and clinical/laboratory features in each disease. We suggesta possibility that serum microRNA levels can be useful markers for diagnosis or evaluatingdisease activities. Furthermore, we revealed that the intermittent overexpression oflet-7a in the mice skin by intraperitoneal injection attenuated the skin fibrosis inducedby bleomycin.
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