| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We establish a streamlined process to generate the dendritic cells from mouse iPS cells and ES cells. To enhance the anti-tumor effect, we generated a ES cell clone expressing IL-15. Furthermore, we generated the macrophages derived from human iPS cells as an effector cells attacking tumor . The iPS cell derived macrophages itself did not show any anti-tumor effects on human melanoma grafted SCID mouse model. However ,genetically modified cytokine producing iPS macrophages show a potent anti tumor effects.
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