| Project/Area Number |
23791297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Research Collaborator |
YAMANISHI Kiyofumi 兵庫医科大学, 医学部, 教授 (10182586)
IMAI Yasutomo 兵庫医科大学, 医学部, 助教 (10529514)
YAMAMOTO Masaaki 兵庫医科大学, 医学部, 助教 (60624640)
SAKAGUCHI Yoshiko 兵庫医科大学, 医学部, 実験補助
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | nuocyte / インターロイキン 33 / 膿疱性乾癬 / ナチュラルヘルパー細胞 / ILC2 / 2型自然リンパ球 / IL-33 / アトピー性皮膚炎 / 乾癬 |
|---|
| Research Abstract |
The IL-1 family members, IL-1beta, IL-18 and IL-33, are proinflammatory cytokines. IL-33 binds to ST2 (IL-1RL1) on nuocytes. The serum levels of IL-1beta and IL-18 in generalized pustular psoriasis (GPP) cases showed positive correlations with the GPP score, WBC and CRP levels. In contrast, none of those 3 clinical markers correlated with serum IL-33 levels in the GPP patients.
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