Role of desmosomal proteins in skin cancer formation, progression and metastasis
Project/Area Number |
23791300
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | Kurume University |
Principal Investigator |
TEYE Kwesi 久留米大学, 医学部, 研究員 (30599303)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 皮膚腫瘍学 / 基底細胞癌 / 有棘細胞癌 / 悪性黒色腫 / デスモゾーム / デスモグレイン / デスモコリン / 皮膚癌治療 |
Research Abstract |
Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) were investigated immunohistochemically for expression of desmosomal proteins. Poorly-differentiated SCC revealed weak positivity for desmocollin 2 and 3, while well-differentiated SCC and BCC revealed strong positivity for them. These results suggested that desmocollin 2 and 3 might play a role in recurrence and metastasis of skin cancer. SCC and BCC also showedstrong positivity for desmoglein 2 and 3.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] How do keratinizing disorders and blistering disorders overlap2013
Author(s)
Hamada T, Tsuruta D, Fukuda S, Ishii N, Teye K, Numata S, Dainichi T, Karashima T, Ohata C, Furumura M,Hashimoto T.
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Journal Title
Exp Dermatol
Volume: 22
Issue: 2
Pages: 83-87
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel adenosine triphosphate (ATP)-binding cassette, subfamily A, member 12 (ABCA12) mutations associated with congenital ichthyosiform erythroderma. Br2012
Author(s)
Fukuda S, Hamada T, Ishii N, Sakaguchi S, Sakai K, Akiyama M, Shimizu H, Masuda K, Izu K, Teye K, Tsuruta D, Karashima T, Nakama T, Yasumoto S, Hashimoto T.
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Journal Title
J Dermatol
Volume: 166(1)
Issue: 1
Pages: 218-221
DOI
Related Report
Peer Reviewed
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