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Roles of Bnip3 in the differentiation and maintenance of epidermis.

Research Project

Project/Area Number 23791304
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionFoundation for Biomedical Research and Innovation

Principal Investigator

MORIYAMA Mariko  公益財団法人先端医療振興財団, 研究員 (40595295)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsケラチノサイト / 発生 / 分化 / オートファジー / 皮膚 / アポトーシス / 角化細胞 / 紫外線照射 / 細胞死 / 転写制御
Research Abstract

Transcriptome analysis of Hes1-/- mouse epidermis revealed the direct relationship between Hes1 and Bnip3, a potent inducer of autophagy. We found that BNIP3 was expressed in the suprabasal layer of the epidermis. We also found that BNIP3 plays a crucial role in keratinocytes differentiation by inducing autophagy. Furthermore, BNIP3 has a protective effect against UVB-induced apoptosis in keratinocytes.

Report

(3 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Tightly regulated and homogeneous transgene expression in human adipose-derived mesenchymal stem cells by lentivirus with tet-off system2013

    • Author(s)
      Moriyama H, Moriyama M, Sawaragi K, Okura H, Ichinose A, Matsuyam A, Hayakawa T
    • Journal Title

      PLOS ONE

      Volume: 8(6)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Tightly regulated and homogeneous transgene expression in human adipose-derived mesenchymal stem cells by lentivirus with tet-off system.2013

    • Author(s)
      Moriyama H
    • Journal Title

      PLOS ONE

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling2012

    • Author(s)
      Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, Matsuyama A, Hayakawa T
    • Journal Title

      BMC Cell Biol

      Volume: 13(1) Pages: 21-21

    • Related Report
      2013 Final Research Report
  • [Journal Article] Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling.2012

    • Author(s)
      Moriyama M
    • Journal Title

      BMC Cell Biol

      Volume: 13 Issue: 1 Pages: 21-21

    • DOI

      10.1186/1471-2121-13-21

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] INDISPENSABLE ROLES OF BNIP3, AN INDUCER OF AUTOPHAGY, IN BOTH DIFFERENTIATION AND MAINTENANCE OF EPIDERMAL KERATINOCYTES.2013

    • Author(s)
      Mariko Moriyama
    • Organizer
      ISSCR 11 th Annual Meeting
    • Place of Presentation
      Boston Convention and Exhibition Center (Boston, MA, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes.2013

    • Author(s)
      Mariko Moriyama
    • Organizer
      2013 International Investigative Dermatology Meeting
    • Place of Presentation
      Edinburgh International Conference Centre (Edinburgh, Scotland)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bcl2ファミリー分子BNIP3が表皮構築に及ぼす影響2012

    • Author(s)
      宇田 純輝
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡 (福岡、日本)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiati on and maintenance of epidermal keratinocytes.2012

    • Author(s)
      Mariko Moriyama
    • Organizer
      37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Loisir Hotel & Spa Tower Naha, Pacific Hotel Okinawa (Naha, Okinawa, Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bcl-2ファミリー分子Bnip3が及ぼす表皮組織分化への影響2011

    • Author(s)
      宇田純輝、森山麻里子、松山晃文、早川堯夫、森山博由
    • Organizer
      第61回日本薬学会近畿支部総会
    • Place of Presentation
      神戸学院大学 ポートアイランドキャンパス
    • Related Report
      2011 Research-status Report
  • [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes

    • Author(s)
      Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
    • Organizer
      11^<th> Annual Meeting, ISSCR
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes

    • Author(s)
      Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
    • Organizer
      第一回皮膚の会
    • Place of Presentation
      岐阜, 高山, 日本
    • Related Report
      2013 Final Research Report
  • [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes

    • Author(s)
      Junki Uda, Mariko Moriyama, Hanayuki Okura, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
    • Organizer
      The 34^<th> annual meeting of the molecular biology society of Japan
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes

    • Author(s)
      Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
    • Organizer
      The 34^<th> annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Okinawa, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Bcl2ファミリー分子BNIP3が表皮構築に及ぼす影響

    • Author(s)
      宇田純輝,森山麻里子,北川綾弓,野村昇吾,松山晃文,森山博由,早川堯夫
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Related Report
      2013 Final Research Report
  • [Presentation] Bcl2 ファミリー分子BNIP3が表皮構築に及ぼす影響

    • Author(s)
      宇田純輝,森山麻里子,北川綾弓,野村昇吾,松山晃文,森山博由,早川堯夫
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Related Report
      2013 Final Research Report
  • [Presentation] Bcl2ファミリー分子BNIP3が表皮構築に及ぼす影響

    • Author(s)
      宇田 純輝
    • Organizer
      第62回 日本薬学会近畿支部総会・大会
    • Place of Presentation
      武庫川女子大学(兵庫、日本)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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