Roles of Bnip3 in the differentiation and maintenance of epidermis.

• Project/Area Number: 23791304
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Foundation for Biomedical Research and Innovation
• Principal Investigator: MORIYAMA Mariko 公益財団法人先端医療振興財団, 研究員 (40595295)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: ケラチノサイト / 発生 / 分化 / オートファジー / 皮膚 / アポトーシス / 角化細胞 / 紫外線照射 / 細胞死 / 転写制御

Research Abstract

Transcriptome analysis of Hes1-/- mouse epidermis revealed the direct relationship between Hes1 and Bnip3, a potent inducer of autophagy. We found that BNIP3 was expressed in the suprabasal layer of the epidermis. We also found that BNIP3 plays a crucial role in keratinocytes differentiation by inducing autophagy. Furthermore, BNIP3 has a protective effect against UVB-induced apoptosis in keratinocytes.

Research Products

• [Journal Article] Tightly regulated and homogeneous transgene expression in human adipose-derived mesenchymal stem cells by lentivirus with tet-off system (2013)
  • Author(s): Moriyama H, Moriyama M, Sawaragi K, Okura H, Ichinose A, Matsuyam A, Hayakawa T
  • Journal Title: PLOS ONE Volume: 8(6)
• [Journal Article] Tightly regulated and homogeneous transgene expression in human adipose-derived mesenchymal stem cells by lentivirus with tet-off system. (2013)
  • Author(s): Moriyama H
  • Journal Title: PLOS ONE Volume: in press
  • Peer Reviewed
• [Journal Article] Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling (2012)
  • Author(s): Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, Matsuyama A, Hayakawa T
  • Journal Title: BMC Cell Biol Volume: 13(1) Pages: 21-21
• [Journal Article] Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. (2012)
  • Author(s): Moriyama M
  • Journal Title: BMC Cell Biol Volume: 13 Issue: 1 Pages: 21-21
  • DOI: 10.1186/1471-2121-13-21
  • Peer Reviewed
• [Presentation] INDISPENSABLE ROLES OF BNIP3, AN INDUCER OF AUTOPHAGY, IN BOTH DIFFERENTIATION AND MAINTENANCE OF EPIDERMAL KERATINOCYTES. (2013)
  • Author(s): Mariko Moriyama
  • Organizer: ISSCR 11 th Annual Meeting
  • Place of Presentation: Boston Convention and Exhibition Center (Boston, MA, USA)
• [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes. (2013)
  • Author(s): Mariko Moriyama
  • Organizer: 2013 International Investigative Dermatology Meeting
  • Place of Presentation: Edinburgh International Conference Centre (Edinburgh, Scotland)
• [Presentation] Bcl2ファミリー分子BNIP3が表皮構築に及ぼす影響 (2012)
  • Author(s): 宇田 純輝
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 (福岡、日本)
• [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiati on and maintenance of epidermal keratinocytes. (2012)
  • Author(s): Mariko Moriyama
  • Organizer: 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Loisir Hotel & Spa Tower Naha, Pacific Hotel Okinawa (Naha, Okinawa, Japan)
• [Presentation] Bcl-2ファミリー分子Bnip3が及ぼす表皮組織分化への影響 (2011)
  • Author(s): 宇田純輝、森山麻里子、松山晃文、早川堯夫、森山博由
  • Organizer: 第61回日本薬学会近畿支部総会
  • Place of Presentation: 神戸学院大学 ポートアイランドキャンパス
• [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes
  • Author(s): Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
  • Organizer: 11^<th> Annual Meeting, ISSCR
  • Place of Presentation: Boston, USA
• [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes
  • Author(s): Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
  • Organizer: 第一回皮膚の会
  • Place of Presentation: 岐阜, 高山, 日本
• [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes
  • Author(s): Junki Uda, Mariko Moriyama, Hanayuki Okura, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
  • Organizer: The 34^<th> annual meeting of the molecular biology society of Japan
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Indispensable roles of BNIP3, an inducer of autophagy, in both differentiation and maintenance of epidermal keratinocytes
  • Author(s): Mariko Moriyama, Junki Uda, Akifumi Matsuyama, Hiroyuki Moriyama, Takao Hayakawa
  • Organizer: The 34^<th> annual meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Okinawa, Japan
• [Presentation] Bcl2ファミリー分子BNIP3が表皮構築に及ぼす影響
  • Author(s): 宇田純輝,森山麻里子,北川綾弓,野村昇吾,松山晃文,森山博由,早川堯夫
  • Organizer: 第62回日本薬学会近畿支部総会・大会
• [Presentation] Bcl2 ファミリー分子BNIP3が表皮構築に及ぼす影響
  • Author(s): 宇田純輝,森山麻里子,北川綾弓,野村昇吾,松山晃文,森山博由,早川堯夫
  • Organizer: 第61回日本薬学会近畿支部総会・大会
• [Presentation] Bcl2ファミリー分子BNIP3が表皮構築に及ぼす影響
  • Author(s): 宇田 純輝
  • Organizer: 第６２回 日本薬学会近畿支部総会・大会
  • Place of Presentation: 武庫川女子大学（兵庫、日本）
• [Remarks]