• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

SSRI administration during adolescent period and suicide risk-serotonin receptors and impulsivity

Research Project

Project/Area Number 23791305
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionHokkaido University

Principal Investigator

OHMURA Yu  北海道大学, 大学院・医学研究科, 助教 (80597659)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsSSRI / 衝動性 / 5-HT2C / 自殺 / 気分障害
Research Abstract

In the present study, we attempted to determine a cause of increased suicide risk due to serotonin reuptake inhibitor (SSRI) administration at adolescent period, focusing on the dysfunction of serotonin receptors and SSRI-induced impulsivity. We successfully developed a behavioral task to assess impulsivity in adolescent rats. The co-administration of a 5-HT2C receptor antagonist and SSRI enhanced impulsivity. However SSRI administration unaltered impulsivity in 5-HT2C receptor knockout mice, inconsistent with above rat study. Thus we were not able to obtain a clear conclusion.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Milnacipran enhances the control of impulsive action by activating D_1-like receptors in the infralimbic cortex.2013

    • Author(s)
      Tsutsui-Kimura I, Ohmura Y, Izumi T, Kumamoto H, Yamaguchi
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 225 Issue: 2 Pages: 495-504

    • DOI

      10.1007/s00213-012-2835-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impulsive Behavior and Nicotinic Acetylcholine Receptors2012

    • Author(s)
      Ohmura Y, Tsutsui-Kimura I, YoshiokaM
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 118 Issue: 4 Pages: 413-422

    • DOI

      10.1254/jphs.11R06CR

    • NAID

      10030571764

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.2012

    • Author(s)
      Ohmura Y, Tsutsui-Kimura I, Kumamoto H, Minami M, Izumi T.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 219 Issue: 2 Pages: 148-153

    • DOI

      10.1007/s00213-011-2496-9

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal2011

    • Author(s)
      Ohmura Y, Jutkiewicz EM、Yoshioka M, Domino EF
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 117 Issue: 2 Pages: 121-124

    • DOI

      10.1254/jphs.11074SC

    • NAID

      10029896243

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] タンドスピロンは衝動的行動を抑制する2012

    • Author(s)
      大村優
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Tandospirone suppresses impulsive action in rats2012

    • Author(s)
      Yu Ohmura, Haruko Kumamoto, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, and Mitsuhiro Yoshioka
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] The Roles of the Infralimbic Cortex in Impulsive Action2011

    • Author(s)
      Ohmura Y
    • Organizer
      ACNP 50th annual meeting
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2011-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] リチウムは衝動的行動を抑制するがバルプロ酸、カルバマゼピンは抑制しない2011

    • Author(s)
      大村優
    • Organizer
      第41回日本神経精神薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi