Genetic research of schizophrenia and autism

• Project/Area Number: 23791312
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Niigata University
• Principal Investigator: WATANABE Yuichiro 新潟大学, 医歯学系, 准教授 (90401744)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 統合失調症 / 自閉症スペクトラム障害 / マイクロ RNA / マイクロRNA / 自閉症 / リシークエンス

Research Abstract

MicroRNAs may play a role in the pathophysiology of schizophrenia and autism spectrum disorders (ASD). To explore risk variations for schizophrenia and ASD, we resequenced MIR137 and performed an association analysis in 1,502 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. These variations did not associate with schizophrenia and ASD. Our resequencing and association analysis of MIR137 failed to find risk variations for schizophrenia and ASD.

Research Products

• [Journal Article] An association analysis of the cardiomyopathy-associated 5 (CMYA5) genewith schizophrenia in a Japanese population. (2013)
  • Author(s): Furukawa M, Tochigi M, Otowa T, Arinami T, Inada T, Ujike H, Watanabe Y, Iwata N, Itokawa M, Kunugi H, Hashimoto R, Ozaki N, Kakiuchi C, Kasai K, Sasaki T
  • Journal Title: Psychiatr Genet. Volume: 23(4) Issue: 4 Pages: 179-180
  • DOI: 10.1097/ypg.0b013e328360c8be
  • Peer Reviewed
• [Journal Article] Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population (2013)
  • Author(s): Egawa, J., Nunokawa, A., Shibuya, M., Watanabe, Y., Kaneko, N., Igeta, H., Someya, T
  • Journal Title: Psychiatry and Clinical Neuroscience Volume: 67(4) Pages: 277-279
  • Peer Reviewed
• [Journal Article] Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population (2013)
  • Author(s): Ikeda, M., Aleksic, B., Yamada, K., Iwayama-Shigeno, Y., Matsuo, K., Numata, S., Watanabe, Y., Ohnuma, T., Kaneko, T., Fukuo, Y., Okochi, T., Toyota, T., Hattori, E., Shimodera, S., Itakura, M., Nunokawa, A., Shibata, N., Tanaka, H., Yoneda, H., Arai, H., Someya, T., Ohmori, T., Yoshikawa, T., Ozaki, N., Iwata, N
  • Journal Title: Molecular Psychiatry Volume: 18(6) Pages: 636-638
  • Peer Reviewed
• [Journal Article] Association between OXTR and clinical phenotypes of autism spectrum disorders (2013)
  • Author(s): Egawa, J., Watanabe, Y. (co-first author), Endo, T., Tamura, R., Masuzawa, N., Someya, T
  • Journal Title: Psychiatry Volume: 208(1) Pages: 99-100
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population (2013)
  • Author(s): Shibata, H., Yamamoto, K., Sun, Z., Oka, A., Inoko, H., Arinami, T., Inada, T., Ujike, H., Itokawa, M., Tochigi, M., Watanabe, Y., Someya, T., Kunugi, H., Suzuki, T., Iwata, N., Ozaki, N., Fukumaki, Y
  • Journal Title: Psychiatric Genetics Volume: 23(3) Pages: 117-123
  • Peer Reviewed
• [Journal Article] Association of the BDNF C270T polymorphism with schizophrenia An updated meta-analysis (2013)
  • Author(s): Watanabe, Y., Nunokawa, A., Someya, T
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 67(2) Pages: 123-125
  • Peer Reviewed
• [Journal Article] A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients (2013)
  • Author(s): Supriyanto, I., Watanabe, Y., Mouri, K., Shiroiwa, K., Ratta-Apha, W., Yoshida, M., Tamiya, G., Sasada, T., Eguchi, N., Okazaki, K., Shirakawa, O., Someya, T., Hishimoto, A
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry Volume: 40 Pages: 347-352
  • Peer Reviewed
• [Journal Article] ssociation of the BDNF C270T polymorphism with schizophrenia: An updated meta-analysis (2013)
  • Author(s): Watanabe, Y., Nunokawa, A., Someya, T.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 67 Issue: 2 Pages: 123-125
  • DOI: 10.1111/pcn.12018
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population. (2013)
  • Author(s): Shibata H, Yamamoto K, Sun Z, Oka A, Inoko H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Suzuki T, Iwata N, Ozaki N, Fukumaki Y
  • Journal Title: Psychiatr Genet Volume: 23(3) Issue: 3 Pages: 117-123
  • DOI: 10.1097/ypg.0b013e32835fe4f1
  • Peer Reviewed
• [Journal Article] Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population (2013)
  • Author(s): Ikeda M, Aleksic B, Yamada K, Iwayama-Shigeno Y, Matsuo K, Numata S, Watanabe Y, Ohnuma T, Kaneko T, Fukuo Y, Okochi T, Toyota T, Hattori E, Shimodera S, Itakura M, Nunokawa A, Shibata N, Tanaka H, Yoneda H, Arai H, Someya T, Ohmori T, Yoshikawa T, Ozaki N, Iwata N
  • Journal Title: Mol Psychiatry Volume: 18(6) Issue: 6 Pages: 636-638
  • DOI: 10.1038/mp.2012.74
  • Peer Reviewed
• [Journal Article] Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population (2013)
  • Author(s): Egawa, J., Nunokawa, A., Shibuya, M., Watanabe, Y., Kaneko, N., Igeta, H., Someya, T.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 67 Issue: 4 Pages: 277-279
  • DOI: 10.1111/pcn.12047
  • Peer Reviewed
• [Journal Article] Oxytocin receptor (OXTR) gene and riskof schizophrenia: Case-control and family-based analyses and meta-analysis in a Japanese population. (2012)
  • Author(s): Watanabe, Y., Kaneko, N., Nunokawa, A., Shibuya, M., Egawa, J., Someya, T
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 66(7) Pages: 622-622
  • Peer Reviewed
• [Journal Article] Supportive evidence for the association between the Gln2Pro polymorphism in the SIGMAR1 gene and schizophrenia in the Japanese population: A case-control study and an updated meta-analysis (2012)
  • Author(s): Watanabe, Y., Nunokawa, A., Kaneko, N., Shibuya, M., Egawa, J., Someya, T
  • Journal Title: Schizophrenia Research Volume: 141(2-3) Pages: 279-280
  • Peer Reviewed
• [Journal Article] Case-control study and meta-analysis of Ser311Cys polymorphism in the DRD2 gene demonstrate lack of association with risk of for schizophrenia in the Japanese population (2012)
  • Author(s): Watanabe, Y., Nunokawa, A., Kaneko, N., Shibuya, M., Egawa, J., Fukui, N., Someya, T
  • Journal Title: Genetics and Molecular Research Volume: 11 Pages: 1142-1145
  • Peer Reviewed
• [Journal Article] A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population (2012)
  • Author(s): Egawa, J., Watanabe, Y., Nunokawa, A., Endo, T., Kaneko, K., Tamura, R., Sugiyama, T., Someya, T
  • Journal Title: Psychiatry Research Volume: 196 Pages: 320-322
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population (2012)
  • Author(s): Watanabe, Y., Egawa, J., Iijima, Y., Nunokawa, A., Kaneko, N., Shibuya, M., Arinami, T., Ujike, H., Inada, T., Iwata, N., Tochigi, M., Kunugi, H., Itokawa, M., Ozaki, N., Hashimoto, R., Someya, T
  • Journal Title: Schizophrenia Research1 Volume: 37 Pages: 264-266
  • Peer Reviewed
• [Journal Article] Association of SNPs linked toincreased expression of SLC1A1 with schizophrenia (2012)
  • Author(s): Horiuchi, Y., Iida, S., Koga, M., Ishiguro, H., Iijima, Y., Inada, T., Watanabe, Y., Someya, T., Ujike, H., Iwata, N., Ozaki, N., Kunugi, H., Tochigi, M., Itokawa, M., Arai, M., Niizato, N., Iritani, S., Kakita, A., Takahashi, H., Nawa, H., Arinami, T
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Volume: 159B Pages: 30-37
  • Peer Reviewed
• [Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia (2012)
  • Author(s): Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159B(1) Issue: 1 Pages: 30-37
  • DOI: 10.1002/ajmg.b.31249
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population (2012)
  • Author(s): Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
  • Journal Title: Schizophr Res Volume: 137(1-3) Issue: 1-3 Pages: 264-266
  • DOI: 10.1016/j.schres.2012.01.034
  • Peer Reviewed
• [Journal Article] Supportive evidence for the association between the Gln2Pro polymorphism in the SIGMAR1 gene and schizophrenia in the Japanese population : A case-control study and an updated meta-analysis (2012)
  • Author(s): Watanabe, Y., Nunokawa, A., Kaneko, N., Shibuya, M., Egawa, J., Someya, T.
  • Journal Title: Schizophrenia Research Volume: 141 Issue: 2-3 Pages: 279-280
  • DOI: 10.1016/j.schres.2012.06.043
  • Peer Reviewed
• [Journal Article] Oxytocin receptor (OXTR) gene and risk of schizophrenia: Case-control and family-based analyses and meta-analysis in a Japanese population (2012)
  • Author(s): Watanabe, Y., Kaneko, N., Nunokawa, A., Shibuya, M., Egawa, J., Someya, T.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 66 Issue: 1 Pages: 622-622
  • DOI: 10.1016/j.psychres.2012.11.007
  • Peer Reviewed
• [Journal Article] A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population (2012)
  • Author(s): 遠藤太郎、染矢俊幸
  • Journal Title: Psychiatry Res Volume: (印刷中) Issue: 2-3 Pages: 320-322
  • DOI: 10.1016/j.psychres.2011.09.001
  • Peer Reviewed
• [Journal Article] Exploration of a possible association between the tryptophan hydroxylase 2 (TPH2) gene and panic symptoms induced by carbon dioxide in healthy individuals (2012)
  • Author(s): Abe R, et al
  • Journal Title: Psychiatry Research Volume: (in press) Issue: 3 Pages: 358-359
  • DOI: 10.1016/j.psychres.2011.11.005
  • Peer Reviewed
• [Journal Article] 援助希求に対する統合失調症教育プログラムの効果 (2012)
  • Author(s): Yoshii H et al.
  • Journal Title: Journal of Health Science Volume: 4 Pages: 33-41
  • Peer Reviewed
• [Journal Article] Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia (2011)
  • Author(s): Deng, X., Takaki, H., Wang, L., Kuroki, T., Nakahara, T., Hashimoto, K., Ninomiya, N., Arinami, T., Inada, T., Ujike, H., Itokawa, M., Tochigi, M., Watanabe, Y., Someya, T., Kunugi, H., Iwata, N., Ozaki, N., Shibata, H., Fukumaki, Y
  • Journal Title: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics Volume: 156 Pages: 850-858
  • Peer Reviewed
• [Journal Article] SLC1A1と統合失調症の関連解析 (2011)
  • Author(s): Horiuchi Y et al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159B Pages: 30-37
  • Peer Reviewed
• [Journal Article] 統合失調症に対するスティグマ (2011)
  • Author(s): Yoshii H et al.
  • Journal Title: BMC Research Notes Volume: 4 Pages: 558-558
  • Peer Reviewed
• [Journal Article] PDE4AおよびPLATと統合失調症との関連解析 (2011)
  • Author(s): Deng X et al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 156B Pages: 850-858
  • Peer Reviewed
• [Journal Article] 知識に対する統合失調症教育プログラムの効果 (2011)
  • Author(s): Yoshii H et al.
  • Journal Title: BMC Public Health Volume: 11 Pages: 323-323
  • Peer Reviewed
• [Journal Article] 統合失調症とマイクロRNA (2011)
  • Author(s): 渡部雄一郎ほか
  • Journal Title: 分子精神医学 Volume: 11 Pages: 179-184
• [Presentation] Rare missense variations of TPH2 and risk of autism: Exon resequensing and association analysis (2012)
  • Author(s): Egawa J, Watanabe Y, Nunokawa A, Endo T, Kaneko N, Tamura R, Sugiyama T, Someya T
  • Organizer: 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry and 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe
• [Presentation] Case-control study and meta-analysis did not confirm an association between DRD2 Ser311Cys and schizophrenia in the Japanese population (2012)
  • Author(s): Watanabe Y, Nunokawa A, Kaneko N, Shibuya M, Egawa J, Fukui N, Igeta H, Someya T
  • Organizer: 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry and 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe
• [Presentation] A case-control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1 (GSTM1) gene and schizophrenia (2012)
  • Author(s): Nunokawa A, Watanabe Y, Kaneko N, Shibuya M, Igeta H, Someya T
  • Organizer: 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry and 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe
• [Book] Pharmacogenomics in psychiatric disorders. In Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation (2013)
  • Author(s): Lam YWF, Fukui N, Sugai T, Watanabe J, Watanabe Y, Suzuki Y, Someya T
  • Publisher: Elsevier
• [Book] Pharmacogenomics in psychiatric disorders (2013)
  • Author(s): Lam YWF, Fukui N, Sugai T, Watanabe J, Watanabe Y, Suzuki Y, Someya T
  • Total Pages: 496
  • Publisher: Elsevier
• [Book] 統合失調症研究の最近の進歩.統合失調症の新たなストラテジー-非定型抗精神病薬によるアプローチ- (2011)
  • Author(s): 北村秀明,渡部雄一郎,染矢俊幸
  • Publisher: 先端医学社