• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pharmacogenomics of impaired glucose metabolism induced by olanzapine

Research Project

Project/Area Number 23791314
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionNiigata University

Principal Investigator

FUKUI Naoki  新潟大学, 医歯学系, 助教 (90535163)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords抗精神病薬 / 糖代謝異常 / 薬理ゲノム学 / 精神医学 / 薬理遺伝学
Research Abstract

Meta-analysis of genome-wide association studies (GWAS) have detected several genetic markers related with type 2 diabetes and insulin / glucose levels after an oral glucose challenge. We have examined relationships between these genetic markers and metabolic abnormalities such as the impaired glucose metabolism and obesity, induced by olanzapine and other antipsychotics. Consequently, we found that, I) the relationship between glucose-dependent insulinotropic polypeptide receptor (GIPR) gene and insulin levels after an oral glucose challenge, II) the relationship between GIPR gene and weight gain induced by olanzapine medication, III ) glucose-dependent insulinotropic polypeptide (GIP) gene and BMI / waist circumference.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (43 results)

All 2013 2012 2011 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (24 results)

  • [Journal Article] Impact of the ABCB1 gene polymorphism on plasma 9-hydroxyrisperidone and active moiety levels in Japanese patients with schizophrenia.2013

    • Author(s)
      Suzuki Y, Tsuneyama N, Fukui N, Sugai T, Watanabe J, Ono S, Saito M, Someya T.
    • Journal Title

      J Clin Psychopharmacol.

      Volume: 33 Issue: 3 Pages: 411-4

    • DOI

      10.1097/jcp.0b013e31828ecd52

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low prevalence of metabolic syndrome and its prediction in Japanese inpatients with schizophrenia.2013

    • Author(s)
      Suzuki Y, Sugai T, Fukui N, Watanabe J, Ono S, Tsuneyama N, Saito M, Someya T.
    • Journal Title

      Hum Psychopharmacol.

      Volume: 28 Issue: 2 Pages: 188-91

    • DOI

      10.1002/hup.2295

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in plasma prolactin levels in patients with schizophrenia treated on monotherapy with five second-generation antipsychotics.2013

    • Author(s)
      Suzuki Y, Sugai T, Fukui N, Watanabe J, Ono S, Tsuneyama N, Saito M, Someya T.
    • Journal Title

      Schizophr Res.

      Volume: 145 Issue: 1-3 Pages: 116-9

    • DOI

      10.1016/j.schres.2012.12.027

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in QT interval after switching to quetiapine in Japanese patients with schizophrenia.2013

    • Author(s)
      Suzuki Y, Sugai T, Fukui N, Watanabe J, Ono S, Tsuneyama N, Saito M, Someya T.
    • Journal Title

      Hum Psychopharmacol.

      Volume: 28 Issue: 1 Pages: 94-6

    • DOI

      10.1002/hup.2277

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Prevalence of glucose intolerance in Japanese schizophrenic patients with a normal fasting glucose level.2013

    • Author(s)
      小野信
    • Journal Title

      J Clin Psychopharmacol

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quetiapine-induced insulin resistance after switching from blonanserin despite a loss in both body weight and waistcircumference.2012

    • Author(s)
      Suzuki Y, Sugai T, Fukui N, Watanabe J, Ono S, Tsuneyama N, Saito M, Someya T
    • Journal Title

      Psychiatry ClinNeurosci

      Volume: 66(6) Issue: 6 Pages: 534-535

    • DOI

      10.1111/j.1440-1819.2012.02388.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in quetiapine-induced hypoglycemia following a switch to blonanserin2012

    • Author(s)
      Suzuki Y, Tsuneyama N, Sugai T, Fukui N, Watanabe J, Ono S, Saito M, Someya T
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66(4) Issue: 4 Pages: 370-371

    • DOI

      10.1111/j.1440-1819.2012.02338.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in QTcprolongation induced by zotepine following a switch to perospirone2012

    • Author(s)
      Suzuki Y, Watanabe J, Sugai T, Fukui N, Ono S, Tsuneyama N, Saito M, Someya T
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66(3) Issue: 3 Pages: 244-244

    • DOI

      10.1111/j.1440-1819.2012.02321.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine.2012

    • Author(s)
      Ono S, Suzuki Y, Fukui N, Sugai T, Watanabe J, Tsuneyama N, Someya T.
    • Journal Title

      Pharmacogenomics J.

      Volume: 12 Issue: 6 Pages: 507-12

    • DOI

      10.1038/tpj.2011.28

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excessive insulin secretion in Japanese schizophrenic patients treated with antipsychotics despite normal fasting glucose levels.2012

    • Author(s)
      Sugai T, Suzuki Y, Fukui N, Watanabe J, Ono S, Tsuneyama N, Someya T.
    • Journal Title

      J Clin Psychopharmacol. 2012 Dec;32(6):750-5.

      Volume: 32 Issue: 6 Pages: 750-5

    • DOI

      10.1097/jcp.0b013e3182742ea4

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The lipid profiles in Japanese patients with schizophrenia treated with antipsychotic agents.2012

    • Author(s)
      Watanabe J, Suzuki Y, Sugai T, Fukui N, Ono S, Tsuneyama N, Saito M, Someya T.
    • Journal Title

      Gen Hosp Psychiatry.

      Volume: 34 Issue: 5 Pages: 525-8

    • DOI

      10.1016/j.genhosppsych.2012.04.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of adipocytokines related to second-generation antipsychotics in normal fasting glucose patients with schizophrenia.2012

    • Author(s)
      Sugai T, Suzuki Y, Fukui N, Ono S, Watanabe J, Tsuneyama N, Someya T.
    • Journal Title

      J Clin Psychopharmacol.

      Volume: 32 Issue: 3 Pages: 390-3

    • DOI

      10.1097/jcp.0b013e3182524393

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the CYP2D6*10 allele on risperidone metabolism in Japanese psychiatricpatients2012

    • Author(s)
      Suzuki Y, Fukui N, Tsuneyama N, Watanabe J, Ono S, Sugai T, Saito M, Inoue Y, Someya T
    • Journal Title

      Hum Psychopharmacol Clin Exp

      Volume: 27(1) Issue: 1 Pages: 43-46

    • DOI

      10.1002/hup.1260

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.2012

    • Author(s)
      Suzuki Y, Fukui N, Watanabe J, Ono S, Sugai T, Tsuneyama N, Saito M, Inoue Y, Someya T.
    • Journal Title

      Hum Psychopharmacol.

      Volume: 27 Issue: 1 Pages: 39-42

    • DOI

      10.1002/hup.1258

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study2012

    • Author(s)
      Watanabe J, Suzuki Y, Fukui N, Ono S, Sugai T, Tsuneyama N, Someya T.
    • Journal Title

      J Clin Psychopharmacol.

      Volume: 32 Issue: 1 Pages: 18-22

    • DOI

      10.1097/jcp.0b013e31823f6f21

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent increase in theQTc interval in aripiprazole treatment after risperidone2011

    • Author(s)
      Suzuki Y, Ono S, Fukui N, Sugai T, Watanabe J, Tsuneyama N, Someya T
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35(2) Issue: 2 Pages: 643-644

    • DOI

      10.1016/j.pnpbp.2010.10.024

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the metabolic parameters and QTc interval after switching from olanzapine to aripiprazole in Japanese patients with stable schizophrenia2011

    • Author(s)
      Suzuki Y, Sugai T, Ono S, Sawamura K, Fukui N, Watanabe J, Tsuneyama N, Someya T
    • Journal Title

      J Clin Psychopharmacol

      Volume: 31(4) Issue: 4 Pages: 526-528

    • DOI

      10.1097/jcp.0b013e318221e80d

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine.2011

    • Author(s)
      小野 信
    • Journal Title

      Pharmacogenomics J

      Volume: doi: 10.1038

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Prevalence of glucose intolerance in Japanese schizophrenic patients with a normal fasting glucose level

    • Author(s)
      Ono S, Suzuki Y, Fukui N, Sugai T, Watanabe J, Tsuneyama N, Saito M, Someya T
    • Journal Title

      J Clin Psychopharmacol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Olanzapine内服による体重増加とGIPR遺伝子多型との関連2012

    • Author(s)
      小野信,鈴木雄太郎,須貝拓朗,福井直樹,渡邉純蔵,常山暢人,斎藤摩美,染矢俊幸
    • Organizer
      第33回日本臨床薬理学会
    • Place of Presentation
      宜野湾
    • Year and Date
      2012-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] GWASで同定されたQT延長遺伝子多型が,抗精神病薬服用中の統合失調症患者のQT間隔に与える影響の検討2012

    • Author(s)
      渡邉純蔵,福井直樹,鈴木雄太郎,須貝拓朗,小野信,常山暢人,斎藤摩美,染矢俊幸
    • Organizer
      第33回日本臨床薬理学会
    • Place of Presentation
      宜野湾
    • Year and Date
      2012-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗精神病薬内服中の統合失調症群におけるBMI・ウエスト径とGIP遺伝子との関連について2012

    • Author(s)
      福井直樹,鈴木雄太郎,須貝拓朗,渡邉純蔵,小野信,常山暢人,斎藤摩美,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗精神病薬がインスリン分泌に与える影響2012

    • Author(s)
      須貝拓朗,鈴木雄太郎,福井直樹,渡邉純蔵,小野信,常山暢人,斎藤摩美,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] GWASで同定されたQT延長関連遺伝子が,抗精神病薬服用中の統合失調症患者のQT間隔に与える影響2012

    • Author(s)
      渡邉純蔵,福井直樹,鈴木雄太郎,須貝拓朗,小野信,常山暢人,斎藤摩美,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] Zotepine内服中に生じた心電図QTc延長がperospironeへの薬剤置換後改善した1例2012

    • Author(s)
      茂木崇治,鈴木雄太郎,渡邉純蔵,須貝拓朗,福井直樹,小野信,常山暢人,斎藤摩美,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] Risperidone代謝と心電図QT間隔との関係2012

    • Author(s)
      鈴木雄太郎,福井直樹,渡邉純蔵,小野信,須貝拓朗,常山暢人,斎藤摩美,井上義政,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] ブロナンセリンからクエチアピンに置換後、体重及びウエスト径の増加を伴わずにインスリン抵抗性が増大した一例2012

    • Author(s)
      斎藤摩美,鈴木雄太郎,須貝拓朗,福井直樹,渡邉純蔵,小野信,常山暢人,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] Olanzapineの治療効果とDRD3 receptor Ser9Gly遺伝子多型の関係2012

    • Author(s)
      小野信,鈴木雄太郎,須貝拓朗,福井直樹,渡邉純蔵,常山暢人,斎藤摩美,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] Risperidone服用中の日本人統合失調症患者のQT間隔に与えるCYP2D6およびABCB1遺伝子多型の影響2012

    • Author(s)
      常山暢人,鈴木雄太郎,福井直樹,須貝拓朗,渡邉純蔵,小野信,斎藤摩美,染矢俊幸
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗精神病薬内服中の統合失調症群におけるBMI・ウエスト径とGIP遺伝子との関連について.2012

    • Author(s)
      福井直樹
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮
    • Related Report
      2012 Annual Research Report
  • [Presentation] Olanzapine内服による体重増加とGIPR遺伝子多型との関連.2012

    • Author(s)
      小野信
    • Organizer
      第33回日本臨床薬理学会
    • Place of Presentation
      宜野湾
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規抗精神病薬の身体リスクとその対応(シンポジウム)2011

    • Author(s)
      須貝拓朗,鈴木雄太郎,福井直樹,渡邉純蔵,小野信,常山暢人,齋藤摩美,染矢俊幸
    • Organizer
      第32回日本臨床薬理学会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 夜間における抗精神病薬に関連したQT間隔延長リスクの増大-24時間ホルター心電図記録を用いた研究から2011

    • Author(s)
      渡邉純蔵,鈴木雄太郎,福井直樹,小野信,須貝拓朗,常山暢人,染矢俊幸
    • Organizer
      第32回日本臨床薬理学会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症患者における糖負荷後のインスリン値とGIPR遺伝子多型との関連2011

    • Author(s)
      小野信,福井直樹,鈴木雄太郎,須貝拓朗,渡邉純蔵,常山暢人,齋藤摩美,染矢俊幸
    • Organizer
      第32回日本臨床薬理学会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] CYP2D6遺伝子多型とrisperidone代謝との関連2011

    • Author(s)
      常山暢人,鈴木雄太郎,福井直樹,須貝拓朗,渡邉純蔵,小野信,齋藤摩美,井上義政,染矢俊幸
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 第2世代抗精神病薬とLDL/HDL比との関連2011

    • Author(s)
      須貝拓朗,鈴木雄太郎,福井直樹,渡邉純蔵,小野信,常山暢人,齋藤摩美,染矢俊幸
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Olanzapineからaripiprazoleへの置換前後における糖脂質代謝関連因子及び心電図QT間隔の比較2011

    • Author(s)
      鈴木雄太郎,須貝拓朗,小野信,澤村一司,福井直樹,渡邉純蔵,常山暢人,染矢俊幸
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗精神病薬服用患者におけるQT間隔とQT延長関連遺伝子との関係2011

    • Author(s)
      渡邉純蔵,鈴木雄太郎,福井直樹,須貝拓朗,小野信,常山暢人,齋藤摩美,染矢俊幸
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Olanzapine内服によるBMI変化量とglucose-dependent insulinotropic polypeptide receptor 遺伝子多型との関連2011

    • Author(s)
      小野信,福井直樹,鈴木雄太郎,須貝拓朗,渡邉純蔵,常山暢人,齋藤摩美,染矢俊幸
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗精神病薬治療の最適化-副作用の視点から-(シンポジウム)2011

    • Author(s)
      鈴木雄太郎,福井直樹,須貝拓朗,渡邉純蔵,小野信,常山暢人,齋藤摩美,染矢俊幸
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 臨床表現型や薬物動態をコントロールすることの重要性について(シンポジウム)2011

    • Author(s)
      福井直樹,鈴木雄太郎,須貝拓朗,渡邉純蔵,小野信,常山暢人,齋藤摩美,染矢俊幸
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 臨床表現型や薬物動態をコントロールすることの重要性について(シンポジウム)2011

    • Author(s)
      福井 直樹
    • Organizer
      第21回日本臨床精神神経薬理学会(招待講演)
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 統合失調症患者における糖負荷後のインスリン値とGIPR遺伝子多型との関連2011

    • Author(s)
      小野 信
    • Organizer
      第32回日本臨床薬理学会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi