| Project/Area Number |
23791316
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 意思決定 / 習慣形成 / モチベーション / 側坐核 / ドパミントーン / 興奮性シナプス伝達 / 個体差 / ストレス / 中脳辺縁ドパミン系 / 報酬学習 / 急性/慢性ストレス / グルタミン酸 / ドーパミントーン |
|---|
| Research Abstract |
Our results suggested that a high-dose administration of a dopamine-receptor partial agonist, aripiprazole, which is thought to block dopamine tone in the nucleus accumbens, would be able to normalize the upregulated excitatory synaptic transmission induced by chronic unpredictable stress or chronic administration of an antidepressant, fluoxetine. In addition, we established a new behavioral measure to reflect motivation, which would depend on dopamine tone in the nucleusaccumbens, and flexible decision making, which would depend on glutamate tone. These resultsprovided clues to understand unknown accumbal role and molecular mechanisms in decision makingand its deficits.
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