Clinical study of novel treatment for drug-inducedhyperprolactinemia

• Project/Area Number: 23791318
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: University of Fukui
• Principal Investigator: ISHITOBI Makoto 福井大学, 医学部, 助教 (50464053)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 統合失調症 / 薬剤性高プロラクチン血症 / pramipexole / 高プロラクチン血症 / 臨床精神薬理

Research Abstract

This pilot study aimed to evaluate the efficacy and tolerability of a low dose of pramipexole, a preferential dopamine D3 receptor agonist, in the treatment of antipsychotics -induced hyperprolactinemia. Forty male patients with schizophrenia who were showing hyperprolactinemia were selected. A few subjects are under treatment withadjunctive low-dosage pramipexole. We reported one of the cases who showed risperidone-induced hyperprolactinemia and ED, each of which was improved successfully without any adverse effect such as worsening psychosis.

Research Products

• [Journal Article] Switching to aripiprazole in subjects with Pervasive Developmental Disorders showingtolerability issues with risperidone (2012)
  • Author(s): Ishitobi M, Hiratani M, Kosaka H, Takahashi T, Mizuno T, Asano M, Murata T, Tomoda A, Wada Y
  • Journal Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 37(1) Pages: 128-31
  • Peer Reviewed
• [Journal Article] Switching to aripiprazole in subjects with Pervasive Developmental Disordersshowing tolerability issues with risperidone (2012)
  • Author(s): Ishitobi M et al.
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry Volume: 37 Pages: 128-31
  • Peer Reviewed
• [Journal Article] Emotional responses associated with self-face processing in individuals with autism spectrum disorders: An fMRI study. (2012)
  • Author(s): Morita T, Kosaka H, Saito DN, Ishitobi M et al.
  • Journal Title: Social neuroscience. Volume: 7 Pages: 223-239
  • Peer Reviewed
• [Journal Article] Adjunctive Treatment With Low-Dosage Pramipexole for Risperidone-Associated Hyperprolactinemia and Sexual Dysfunction in a Male Patient With Schizophrenia (2011)
  • Author(s): Ishitobi M, Kosaka H, Shukunami K, Murata T, Wada Y
  • Journal Title: Journal of Clinical Psychopharmacology Volume: 31(2) Pages: 243-5
  • Peer Reviewed
• [Journal Article] Comment on "Dose-Dependent Effects of Adjunctive Treatment With Aripiprazole on Hyperprolactinemia Induced by Risperidone in Female Patients With Schizophrenia" (2011)
  • Author(s): Ishitobi M, Kosaka H, Shukunami K, Murata T, Wada Y
  • Journal Title: Journal of Clinical Psychopharmacology Volume: 31(3) Pages: 400-1
  • Peer Reviewed