Analysis of epigenetic abnormality in the fetal brain exposed to autism related environment factors in mice.

• Project/Area Number: 23791322
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: University of Fukui (2012); Hamamatsu University School of Medicine (2011)
• Principal Investigator: IWATA Keiko 福井大学, 子どものこころの発達研究センター, 特命助教 (30415088)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 児童 / 思春期精神医学 / 神経科学 / 自閉症 / 環境要因 / 遺伝要因

Research Abstract

I have found that time-specific effects of poly (I:C), which mimic a bacterial and viral infections, on methyltransferases in the brain of embryos in a part-specific manner.Additionally, the expressions of some candidate genes for autism change part-specific manner, and these genes are identified as viral infection susceptibility genes.

Research Products

• [Journal Article] Vldlr overexpression causes hyperactivity in rats (2012)
  • Author(s): Iwata K, Izumo N, Matsuzaki H, Manabe T, Ishibashi Y, Ichitani Y, Yamada K, Thanseem I, Anitha A, Vasu MM, Shimmura C, Wakuda T, Kameno K, Takahashi T, Iwata Y, Suzuki K, NakamuraK, Mori N
  • Journal Title: Mol Autism Volume: 3(1) Pages: 11-11
  • Peer Reviewed
• [Journal Article] Vldlr overexpression causes hyperactivity in rats. (2012)
  • Author(s): Iwata K
  • Journal Title: Mol Autism. Volume: 3 Issue: 1 Pages: 11-11
  • DOI: 10.1186/2040-2392-3-11
  • Peer Reviewed
• [Journal Article] Investigation of the serum levels of anterior pituitary hormones in male children with autism (2011)
  • Author(s): Iwata K, Matsuzaki H, Miyachi T, Shimmura C, Suda S, Tsuchiya KJ,Matsumoto K, Suzuki K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Sato K, Mori N
  • Journal Title: Mol Autism Volume: 2(1) Pages: 16-16
  • Peer Reviewed
• [Journal Article] Investigation of the serum levels of anterior pituitary hormones in male children with autism (2011)
  • Author(s): Iwata K, Matsuzaki H, Miyachi T, et al.
  • Journal Title: Mol Autism Volume: 2(1) Issue: 1 Pages: 16-16
  • DOI: 10.1186/2040-2392-2-16
  • Peer Reviewed
• [Journal Article] Altering the expression balance of hnRNP C1 and C2 changes the expression of myelination-related genes. (2011)
  • Author(s): Iwata K, Matsuzaki H, Manabe T, Mori N.
  • Journal Title: Psychiatry Research Volume: 190 Issue: 2-3 Pages: 364-366
  • DOI: 10.1016/j.psychres.2011.05.043
  • Peer Reviewed
• [Presentation] Is Hypoxia the Remote-Controller for Schizophrenia Genes? EPA-EU GEI Conference (2012)
  • Author(s): Paparelli A, Iwata K, Iyegbe C, Matsuzaki H, Wakuda T, Di Forti M, Jhon P, Murray RM, Takei N
  • Organizer: Maastricht
  • Place of Presentation: Netherlands
• [Presentation] Serum levels of anterior pituitary hormones in children with autism (2012)
  • Author(s): Iwata, K., Matsuzaki, H., and Mori, N
  • Organizer: 2012 International Meeting for Autism Research, Sheraton Centre Toronto
  • Place of Presentation: Toronto, Canada
• [Presentation] VLDL-Specific hypolipidemia pattern in human subjects with autism and autistic models (2012)
  • Author(s): Matsuzaki H, Iwata K, and Mori, N
  • Organizer: 2012 International Meeting for Autism Research
  • Place of Presentation: Toronto, Canada
• [Presentation] Alteration of the expression balance of hnRNP C1 and C2 changes the expression of myelination- and schizophrenia-related genes in the human neuroblastoma cell line (2012)
  • Author(s): Iwata, K., Matsuzaki, H., Takei N, and Mori, N
  • Organizer: 3rd Biennial Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
• [Presentation] Alteration of several schizophrenia candidate genes expression in medial prefrontal cortex in perinatal asphyxia rodent model. (2012)
  • Author(s): Wakuda T, Iwata K, Suzuki K, Takei, N, and Mori N
  • Organizer: 3rd Biennial Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
• [Presentation] 自閉症死後脳縫線核メチル化状態の網羅的解析 (2012)
  • Author(s): 岩田圭子、中林一彦、松崎秀夫、中村和彦、秦健一郎、森則夫
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 小倉市,リーガロイヤルホテル小倉
• [Presentation] Genome-wide DNA methylation profiles in post-mortem brains from subjects with autism (2012)
  • Author(s): Iwata K, Nakamura K, Matsuzaki H, Nakamura K, Hata K, Mori N
  • Organizer: m brains from subjects with autism. The 55thAnnual Meeting of Japanese Society for Neurochemistry
  • Place of Presentation: Kobe Convention Center
• [Presentation] Alteration of the expression balance of hnRNP C1 and C2 changes the expression of myelination- and schizophrenia-related genes in the human neuroblastoma cell line. (2012)
  • Author(s): Iwata K, Matsuzaki H, Takei N, Mori N
  • Organizer: 3rd Biennial Schizophrenia International Research Society Conference
  • Place of Presentation: Florence
• [Presentation] hnRNP C1および C2 発現パターンの変化がミエリン関連遺伝子の発現に及ぼす影響 (2011)
  • Author(s): 岩田圭子、松崎秀夫、森則夫
  • Organizer: 第38回日本脳科学会
  • Place of Presentation: 那覇市,沖縄県市町村自治会館
• [Presentation] Alteration of the expression balance ofhnRNP C1 and C2 changes the expressionof myelination-related genes in the human neuroblastoma cell line. (2011)
  • Author(s): Iwata, K., Matsuzaki, H., Mori, N
  • Organizer: The 54th Annual Meeting of Japanese Society for Neurochemistry
  • Place of Presentation: Kaga, Ruriko
• [Presentation] hnRNP C1 および C2 発現パターンの変化がミエリン関連遺伝子の発現に及ぼす影響 (2011)
  • Author(s): 岩田圭子、松崎秀夫、眞部孝幸、森則夫
  • Organizer: RNA フロンティアミーティング2011
  • Place of Presentation: 大府市,あいち健康プラザ
• [Presentation] hnRNP C1および C2発現パターンの変化がミエリン関連遺伝子の発現に及ぼす影響 (2011)
  • Author(s): 岩田圭子、松崎秀夫、森則夫
  • Organizer: 日本脳科学会
  • Place of Presentation: 那覇