Biological basis and possible tailor-made therapy of developmental disabilities with problematic social behavior
| Project/Area Number |
23791327
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
OKADA Takashi 名古屋大学, 医学部附属病院, 准教授 (80335249)
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| Research Collaborator |
USAMI Masahide 国立国際医療研究センター, 国府台病院, 医師
SUGIYAMA Yuka 名古屋大学, 医学部附属病院精神科, 医師
MORIKAWA Mako 名古屋大学, 大学院医学系研究科
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 行動障害 / 社会認知 / 実行機能 / 神経基盤 / コピー数変異 / 併存障害 / 薬物療法 / 行動療法 / 自閉スペクトラム症 / 表現型 / 機能障害 / ゲノム / 神経心理学機能 / 異種性 / テーラーメイド治療 / 自閉症スペクトラム / 注意欠如・多動性障害 / 視線 / 注意機能 / 発達障害 / 治療介入 / 対人認知 / 社会的行動障害 |
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| Outline of Final Research Achievements |
Children and adolescents with autism spectrum disorders (ASD), attention-deficit hyperactivity disorders (ADHD), or major depressive disorders were examined by standardized questionnaires. As a result, their social behavioral disturbances were associated with ADHD symptoms or oppositional defiant behavior, and partly with ASD tendency or depressive state. These results indicates the relationship between symptomatology of developmental disorders and social behavioral disturbances. Neuropsychological basis of mental disorders with social behavioral disturbances were examined; exploratory eye movement, attention shift for gaze direction and executive functions. In addition, we analyzed a large number of DNA samples, and reported part of the findings. We review a large number of previous studies and propose a guideline on the intervention for social behavioral disturbances. Further studies are needed to develop a tailor-made therapy.
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Report
(5 results)
Research Products
(75 results)
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[Journal Article] Concerns expressed by parents of children with pervasive developmental disorders for different time periods of the day: A case-control study2015
Author(s)
Yoshinori Sasaki, Masahide Usami, Daimei Sasayama, Takashi Okada, Yoshitaka Iwadare, Kyota Watanabe, Hirokage Ushijima, Tetsuya Tanaka, Maiko Harada, Hiromi Tanaka, Masaki Kodaira, Nobuhiro Sugiyama, Tetsuji Sawa, Kazuhiko Saito
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Journal Title
PLoS One
Volume: 10(4)
Issue: 4
Pages: e0124692-e0124692
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Resequencing and association analysis of PTPRA, a possible susceptibility gene for schizophrenia and autism spectrum disorders2014
Author(s)
Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N
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Journal Title
PLoS One
Volume: 9(11)
Issue: 11
Pages: e112531-e112531
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia2014
Author(s)
Chenyao Wang, Takayoshi Koide, Hiroki Kimura, Shohko Kunimoto, Yukako Nakamura, Itaru Kushima, Masahiro Banno, Naoko Kawano, Yuto Takasaki, Jingrui Xing, Branko Aleksic, Masashi Ikeda, Takashi Okada, Tetsuya Iidaka, Toshiya Inada, Nakao Iwata, Norio Ozaki
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Journal Title
Schizophrenia Research
Volume: in print
Related Report
Peer Reviewed
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[Journal Article] Common variants in BCL9 gene and schizophrenia in a Japanese population: Association study, meta-analysis and cognitive function analysis2013
Author(s)
Tomoko Shiino, Takayoshi Koide, Itaru Kushima, Masashi Ikeda, Shohko Kunimoto, Yukako Nakamura, Akira Yoshimi, Branko Aleksic, Masahiro Banno, Tsutomu Kikuchi, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Takashi Okada, Toshiya Inada, Hiroshi Ujike, Tetsuya Iidaka, Michio Suzuki, Nakao Iwata, Norio Ozaki
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Journal Title
J Med Biochem
Volume: 32(4)
Issue: 4
Pages: 351-357
DOI
Related Report
Peer Reviewed
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[Journal Article] The postpartum depressive state in relation to perceived rearing: a prospective cohort study.2012
Author(s)
Hayakawa N, Koide T, Okada T, Murase S, Aleksic B, Furumura K, Shiino T, Nakamura Y, Tamaji A, Ishikawa N, Ohoka H, Usui H, Banno N, Morita T, Goto S, Kanai A, Masuda T, Ozaki N
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Journal Title
PLoS One
Volume: 7
Issue: 11
Pages: e50220-e50220
DOI
Related Report
Peer Reviewed
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[Journal Article] Prospective study on the association between harm avoidance and postpartum depressive state in a maternal cohort of Japanese women.2012
Author(s)
Furumura K, Koide T, Okada T, Murase S, Aleksic B, Hayakawa N, Shiino T, Nakamura Y, Tamaji A, Ishikawa N, Ohoka H, Usui H, Banno N, Morita T, Goto S, Kanai A, Masuda T, Ozaki N.
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Journal Title
PLoS One
Volume: 7
Issue: 4
Pages: e34725-e34725
DOI
Related Report
Peer Reviewed
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[Journal Article] アルコール関連肝不全に対する肝移植の適応基準に関する心理社会的側面2012
Author(s)
木村 宏之, 佐藤 直弘, 大林 昌子, 小山 真弓, 小久保 勲, 藤岡 史枝, 山口 尚子, 坪井 千里, 亀井 秀弥, 大西 康晴, 岡田 俊, 木内 哲也, 尾崎 紀夫
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Journal Title
日本アルコール・薬物医学会雑誌
Volume: 47
Pages: 234-241
NAID
Related Report
Peer Reviewed
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