Connectivity analysis for neural basis of decision-making process and symptoms of schizophrenia

• Project/Area Number: 23791329
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: MIYATA Jun 京都大学, 医学(系)研究科(研究院), 助教 (90549099)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 統合失調症 / connectivity / 意思決定 / 拡散テンソル画像 / Surface-based approach / トラクトグラフィ / Surface- based approach / Voxel-based morphometry / TBSS / コネクティビティ / 主観的QOL / 構造的connectivity / 視床ー皮質経路 / 眼窩前頭皮質

Research Abstract

Neural basis of decision-making process and symptoms of schizophrenia was investigated by means of connectivity analysis. First, global association between cortical thinning and white matter integrity reduction was found in Schizophrenia. Next, in the pathway between thalamus and orbitofrontal cortex, which is deeply involved in decision-making, reduced white matter integrity was associated with cortical thinning in schizophrenia. Finally, correlation between regional gray matter reduction and subjective quality of life was revealed in schizophrenia.

Research Products

• [Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia. (2014)
  • Author(s): Sasamoto, A., Miyata, J., Kubota, M., Hirao, K., Kawada, R., Fujimoto, S., Tanaka, Y., Hazama, M., Sugihara, G., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: Schizophrenia Bulletin Volume: 40 Issue: 2 Pages: 420-427
  • DOI: 10.1093/schbul/sbt030
  • NAID: 120005619771
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impaired empathic abilities and reduced white matter integrity in schizophrenia. (2014)
  • Author(s): Fujino, J., Takahashi, H., Miyata, J., Sugihara, G., Kubota, M., Sasamoto, A., Fujiwara, H., Aso, T., Fukuyama, H., & Murai, T.
  • Journal Title: Progress in Neuropsychopharmacology & Biological Psychiatry Volume: 48 Pages: 117-123
  • DOI: 10.1016/j.pnpbp.2013.09.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia. (2013)
  • Author(s): Kubota, M., Miyata, J., Sasamoto, A., Sugihara, G., Yoshida, H., Kawada, R., Fujimoto, S., Tanaka, Y., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: JAMA Psychiatry Volume: 70 Issue: 1 Pages: 12-21
  • DOI: 10.1001/archgenpsychiatry.2012.1023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Regional gray matter reduction correlates with subjective quality of life in schizophrenia. (2013)
  • Author(s): Ubukata, S., Miyata, J., Yoshizumi, M., Uwatoko, T., Hirao, K., Fujiwara, H., Kawada, R., Fujimoto, S., Tanaka, Y., Kubota, M., Sasamoto, A., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: Journal of Psychiatric Research Volume: 47 Issue: 4 Pages: 548-554
  • DOI: 10.1016/j.jpsychires.2013.01.002
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 統合失調症における思考の柔軟性-認知的完結欲求と安静時脳活動の相関 (2014)
  • Author(s): 磯部昌憲、宮田淳、横山如人、森康生、杉原玄一、村井俊哉、高橋英彦
  • Organizer: 第9回日本統合失調症学会
  • Place of Presentation: 京都
• [Presentation] 統合失調症における思考の柔軟性ー認知的完結欲求と安静時脳活動の相関 (2014)
  • Author(s): 磯部昌憲、宮田淳、横山如人、森康生、杉原玄一、村井俊哉、高橋英彦
  • Organizer: 日本統合失調症学会
  • Place of Presentation: 京都
• [Presentation] Reduced thalamo-prefrontal connectivity and cortical thinning in schizophrenia (2011)
  • Author(s): Manabu Kubota, Jun Miyata, et al.
  • Organizer: The 41st annual meeting of Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] The correlational research between deterioration of WM integrity and thickness/volume of GM in schizophrenia subjects (2011)
  • Author(s): Akihiko Sasamoto, Jun Miyata, et al.
  • Organizer: 第6回統合失調症学会
  • Place of Presentation: 札幌
• [Remarks] プレスリリース
  • URL: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/120904_1.htm