Functional analysis of schizophrenia riskgene CHI3L1
Project/Area Number |
23791331
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
|
Research Institution | Osaka University |
Principal Investigator |
YAMAMORI Hidenaga 大阪大学, 大学院・医学系研究科, 寄附講座助教 (90570250)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 統合失調症 / CHI3LI / 脳表現型 / CHI3L1 / ヒト脳表現型 |
Research Abstract |
We recently reported a significant association between schizophrenia and SNP rs4950928, which is located in the promoter region of the CHI3L1 gene, in a Japanese population. The aim of this study is to see the effect of CHI3L1 gene on various phenotypes of brain, like neurocognition, neuroimaging, neurophysiology, personality trait and gene expressions. We also investigated the differential expression of this gene in schizophrenia. We found the differential expression of CHI3L1 gene in schizophrenia. We also found the association between the risk SNP and the personality trait; Self-Transcendence or the expression of this gene and protein.
|
Report
(3 results)
Research Products
(22 results)
-
-
-
-
[Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening2012
Author(s)
Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
-
Journal Title
Related Report
-
-
-
[Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
-
Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Issue: 4
Pages: 405-413
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait2012
Author(s)
Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
-
Journal Title
Neurosci Lett
Volume: 513(3)
Pages: 204-208
Related Report
Peer Reviewed
-
[Journal Article] A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait2012
Author(s)
Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
-
Journal Title
Neurosci Lett
Volume: (Epub ahead of print)
Issue: 2
Pages: 204-208
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-