The role of the schizophrenia-related molecule, DBZ, in brain plasticity

• Project/Area Number: 23791332
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: TAKAMURA Hironori 大阪大学, 連合小児発達学研究科, 助教 (80514398)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 統合失調症 / DBZ / 脳可塑性 / 抑制性神経細胞

Research Abstract

We observed the role of DBZ (DISC1-binding zinc finger protein), a schizophrenia related molecule, in the development of inhibitory neurons. DBZ has been reported to be an important factor in brain plasticity and also in the development of schizophrenia. We found that DBZ regulated the development of basket cells, a morphologically defined class of parvalbumin (PV)-containing interneurons. We also found that DBZ regulated the level of mRNAs for the gamma-aminobutyric acid (GABA)-synthesizing enzyme GAD67.
These findings suggest that DBZ regulates the development of inhibitory neurons and brain plasticity, which may play an important role in schizophrenia.

Research Products

• [Journal Article] DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes (2014)
  • Author(s): Hattori T, Shimizu S, Koyama Y, Emoto H, Matsumoto Y, Kumamoto N, Yamada K, Takamura H, Matsuzaki S, Katayama T, Tohyama M, Ito A.
  • Journal Title: PLoS One Volume: 9(2)
• [Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-βaccumulation modifier (2014)
  • Author(s): Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 111(7) Pages: 2638-43
• [Journal Article] DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes. (2014)
  • Author(s): Hattori T, Shimizu S, Koyama Y, Emoto H, Matsumoto Y, Kumamoto N, Yamada K, Takamura H, Matsuzaki S, Katayama T, Tohyama M, Ito A.
  • Journal Title: PLoS One Volume: 7;9(2) Issue: 2 Pages: e88506-e88506
  • DOI: 10.1371/journal.pone.0088506
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier (2014)
  • Author(s): Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
  • Journal Title: Proc. Acad. Natl. Sci. USA Volume: 111 Issue: 7 Pages: 2638-2643
  • DOI: 10.1073/pnas.1307345111
  • Peer Reviewed / Open Access
• [Journal Article] XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration (2013)
  • Author(s): Magome T, Hattori T, Taniguchi M, Ishikawa T, Miyata S, Yamada K, Takamura H, Matsuzaki S, Ito A, Tohyama M, Katayama T.
  • Journal Title: Neurochem Int Volume: 63(6) Pages: 561-569
• [Journal Article] DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices (2013)
  • Author(s): Koyama Y, Hattori T, Shimizu S, Taniguchi M, Yamada K, Takamura H, Kumamoto N, Matsuzaki S, Ito A, Katayama T, Tohyama M.
  • Journal Title: J Chem Neuroanat Volume: 53 Pages: 1-10
• [Journal Article] XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration (2013)
  • Author(s): Magome T, Hattori T, Taniguchi M, Ishikawa T, Miyata S, Yamada K, Takamura H, Matsuzaki S, Ito A, Tohyama M, Katayama T
  • Journal Title: Neurochemistry International Volume: 63 Issue: 6 Pages: 561-569
  • DOI: 10.1016/j.neuint.2013.09.011
  • Peer Reviewed
• [Journal Article] DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices. (2013)
  • Author(s): Koyama Y, Hattori T, Shimizu S, Taniguchi M, Yamada K, Takamura H, Kumamoto N, Matsuzaki S, Ito A, Katayama T, Tohyama M.
  • Journal Title: J Chem Neuroanat. Volume: 53 Pages: 1-10
  • DOI: 10.1016/j.jchemneu.2013.07.002
  • Peer Reviewed
• [Journal Article] TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression (2012)
  • Author(s): Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T.
  • Journal Title: PLoS One Volume: 7(12)
• [Journal Article] Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum (2011)
  • Author(s): Takemoto K, Miyata S, Takamura H, Katayama T, Tohyama M.
  • Journal Title: Neurochem Int Volume: 58(8) Pages: 880-7
• [Presentation] プレセニリンキメラ体を用いたガンマセクレターセ機能制御に対する検討 (2014)
  • Author(s): 松崎伸介、高村明孝、三好耕、遠山正彌、Paul Fraser、片山泰一
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 栃木県下野市
• [Presentation] Presenilin 1/2キメラ体を用いたγセクレターゼ機能制御領域の検討 (2013)
  • Author(s): 松崎伸介、高村明孝、三好耕、石川淑子、馬込卓弥、宮武祐樹、遠山正彌、Paul Fraser、片山泰一
  • Organizer: 日本解剖学会第89回近畿支部学術集会
  • Place of Presentation: 奈良県生駒市
  • Year and Date: 2013-11-30
• [Presentation] 精神遅滞関連因子Xpn/KIAA2022はPC12細胞において細胞間・細胞―基質接着に影響し細胞移動を制御する (2013)
  • Author(s): 馬込卓弥、服部剛志、谷口学、石川淑子、山田浩平、高村明孝、三好耕、松崎伸介、遠山正彌、片山泰一
  • Organizer: 日本解剖学会第89回近畿支部学術集会
  • Place of Presentation: 奈良県生駒市
  • Year and Date: 2013-11-30
• [Presentation] 抑肝散による小胞体ストレス細胞死抑制におけるSUMO化の役割 (2013)
  • Author(s): 松崎伸介、渡部音哉、岡村麻美、高村明孝、山田浩平、遠山正彌、片山泰一
  • Organizer: 抑肝散の基礎薬理研究会第9回研究報告会
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2013-11-27
• [Presentation] TRAP1 controls mitochondrial morphology through Drp1 and Mff expression (2013)
  • Author(s): Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T. Neuro
  • Organizer: Joint conference of : The 36th Annual Meeting of the Japan Neuroscience Society, The 56th Annual Meeting of Japanese Society for Neurochemistry, The 23rd Annual Meeting Conference of the Japanese Neural Network Society
  • Place of Presentation: Kyoto, Japan
• [Presentation] Mental retardation- related molecule, Xpn regulates cell-cell and cell-matrix adhesion and migration in PC12 cells (2013)
  • Author(s): Magome T, Hattori T, Taniguchi M, Matsuzaki S, Yamada K, Takamura H, Ishikawa T, Tohyama M, Katayama T. Neuro
  • Organizer: Joint conference of : The 36th Annual Meeting of the Japan Neuroscience Society, The 56th Annual Meeting of Japanese Society for Neurochemistry, The 23rd Annual Meeting Conference of the Japanese Neural Network Society
  • Place of Presentation: Kyoto, Japan
• [Presentation] Involvement of SUMOylation in cell death under ER stress (2013)
  • Author(s): Matsuzaki S, Watanabe O, Okamura A, Takamura H, Yamada K, Tohyama M, Katayama T. Neuro
  • Organizer: Joint conference of : The 36th Annual Meeting of the Japan Neuroscience Society, The 56th Annual Meeting of Japanese Society for Neurochemistry, The 23rd Annual Meeting Conference of the Japanese Neural Network Society
  • Place of Presentation: Kyoto, Japan
• [Presentation] Phosphorylated stathmin1 regulates neurite elongation (2013)
  • Author(s): Yamada K, Taniguchi M, Matsuzaki S, Takamura H, Hattori T, Tohyama M, Katayama T. Neuro
  • Organizer: Joint conference of : The 36th Annual Meeting of the Japan Neuroscience Society, The 56th Annual Meeting of Japanese Society for Neurochemistry, The 23rd Annual Meeting Conference of the Japanese Neural Network Society
  • Place of Presentation: Kyoto, Japan
• [Presentation] TRAP1による分裂因子Drp1、Mff発現制御とミトコンドリア形態変化 (2013)
  • Author(s): 高村明孝,小山佳久、松﨑伸介、山田浩平、服部剛志、宮田信吾、遠山正彌、片山泰一
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 香川県高松市
• [Presentation] 小胞体ストレス性細胞死におけるSUMO化の関与 (2013)
  • Author(s): 松崎伸介,渡部音哉,岡村麻美,高村明孝,山田浩平,遠山正彌,片山泰一
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 香川県高松市
• [Presentation] Presenilin 1/2 キメラ体を用いたγセクレターゼ機能制御領域の検討 (2013)
  • Author(s): 松崎伸介、高村明孝、三好 耕、石川淑子、馬込卓弥、宮武祐樹、遠山正彌、Paul Fraser、片山泰一
  • Organizer: 日本解剖学会第89回近畿支部学術集会
  • Place of Presentation: 奈良県生駒市
• [Presentation] 抑肝散による小胞体ストレス細胞死抑制におけるSUMO化の役割 (2013)
  • Author(s): 松崎 伸介、渡部 音哉、岡村 麻美、高村 明孝、山田 浩平、遠山 正彌、片山 泰一
  • Organizer: 抑肝散の基礎薬理研究会 第9回研究報告会
  • Place of Presentation: 大阪府吹田市
• [Presentation] TRAP1 controls mitochondrial morphology through Drp1 and Mff expression. (2013)
  • Author(s): Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T.
  • Organizer: Neuro2013 (Joint conference)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Mental retardation- related molecule, Xpn regulates cell-cell and cell-matrix adhesion and migration in PC12 cells. (2013)
  • Author(s): Magome T, Hattori T, Taniguchi M, Matsuzaki S, Yamada K, Takamura H, Ishikawa T, Tohyama M, Katayama T.
  • Organizer: Neuro2013 (Joint conference)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Involvement of SUMOylation in cell death under ER stress. (2013)
  • Author(s): Matsuzaki S, Watanabe O, Okamura A, Takamura H, Yamada K, Tohyama M, Katayama T.
  • Organizer: Neuro2013 (Joint conference)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Phosphorylated stathmin1 regulates neurite elongation. (2013)
  • Author(s): Yamada K, Taniguchi M, Matsuzaki S, Takamura H, Hattori T, Tohyama M, Katayama T.
  • Organizer: Neuro2013 (Joint conference)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Involvement of TRAP1 in morphological changes of mitochondria through the regulation of mitochondrial fission proteins (2012)
  • Author(s): Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T
  • Organizer: Neuroscience2012 (Society for neuroscience 42nd Annual Meeting)
  • Place of Presentation: New Orleans, USA
• [Presentation] TRAP1 regulates expression of mitochondrial fission proteins and morphology of mitochondria (2012)
  • Author(s): Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry/The 55th Annual Meeting of the Japanese Society for Neurochemistry joint meeting
  • Place of Presentation: Kobe, Japan
• [Presentation] KIAA2022 is expressed transiently and regulates neurite outgrowth (2012)
  • Author(s): Ishikawa T, Miyata S, Koyama Y, Matsuzaki S, Yamada K, Takamura H, Magome T, Katayama T, Tohyama M
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry/The 55th Annual Meeting of the Japanese Society for Neurochemistry joint meeting
  • Place of Presentation: Kobe, Japan
• [Presentation] Involvement of SUMOylation in ER stress pathway (2012)
  • Author(s): Watanabe O, Matsuzaki S, Takamura H, Yamada K, Fraser P, Tohyama M, Katayama T
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry/The 55th Annual Meeting of the Japanese Society for Neurochemistry joint meeting
  • Place of Presentation: Kobe, Japan
• [Presentation] Involvement of SUMOylation in Plaque and Tangle Pathology (2012)
  • Author(s): Matsuzaki S, Yamada K, St George-Hyslop N, Takamura H, Katayama T, Tohyama M, Raught B, Fraser P
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry/The 55th Annual Meeting of the Japanese Society for Neurochemistry joint meeting
  • Place of Presentation: Kobe, Japan
• [Presentation] SUMOylation Connections to Plaque and Tangle Pathology (2012)
  • Author(s): Matsuzaki S, Yamada K, Takamura H, Tohyama M, Katayama T, Raught B, Fraser P.
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] Transient expression of KIAA2022 during brain development and participation in neurite outgrowth (2012)
  • Author(s): Ishikawa T, Miyata S, Koyama Y, Matsuzaki S, Yamada K, Takamura H, Magome T, Katayama T, Tohyama M.
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] Involvement of TRAP1 in regulation of mitochondrial morphology (2011)
  • Author(s): Takamura H, Miyata S, Takemoto K, Koyama Y, Matsuzaki S, Tohyama M, Katayama T.
  • Organizer: The 54th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Ishikawa, Japan
• [Presentation] C57/BL6 JマウスにおけるDisrupted-in-Schizophrenia 1(DISC1)の新規isoformの同定とそのmRNA発現解析 (2011)
  • Author(s): 宮武祐樹、山田浩平、高村明孝、服部剛志、小山佳久、谷口学、片山泰一、遠山正彌
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都市左京区
• [Presentation] TRAP1 regulates mitochondrial dynamics through the fission proteins in neuronal cells (2011)
  • Author(s): Takamura H, Miyata S, Takemoto K, Koyama Y, Matsuzaki S, Tohyama M, Katayama T.
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan