| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We explored the differential expression of stress-related genes in the postmortem brains of suicide victims and conducted genetic associations of the candidate genes of suicide and schizophrenia. Although we found no evidence of expression difference of stress-related genes such as CRH, we found significant reduced expression of BDNF and DISC1 immunoreactivity in the suicide victims. In addition, we found significant genetic association of DISC1 and EP1 with suicide and schizophrenia. Our findings suggest that suicidal behavior is involved in the genetic vulnerability and that certain polymorphisms might be useful for a biomarker of suicidal behavior.
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