Differential expression of CRF and its stress-related genes in the postmortem brains of suicide victims
Project/Area Number |
23791333
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Kobe University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 臨床精神分子遺伝学 / 自殺 / 死後脳 / CRF / FKBP5 / EP1 / 神経栄養因子 / BDNF / 関連解析 / 死後脳研究 / ケース・コントロール研究 / プロスタノイド系神経伝達 / EP1遺伝子 / UCN1 |
Research Abstract |
We explored the differential expression of stress-related genes in the postmortem brains of suicide victims and conducted genetic associations of the candidate genes of suicide and schizophrenia. Although we found no evidence of expression difference of stress-related genes such as CRH, we found significant reduced expression of BDNF and DISC1 immunoreactivity in the suicide victims. In addition, we found significant genetic association of DISC1 and EP1 with suicide and schizophrenia. Our findings suggest that suicidal behavior is involved in the genetic vulnerability and that certain polymorphisms might be useful for a biomarker of suicidal behavior.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.2013
Author(s)
Supriyanto I, Watanabe Y, Mouri K, Shiroiwa K, Ratta-Apha W, Yoshida M, Tamiya G, Sasada T, Eguchi N, Okazaki K, Shirakawa O, Someya T, Hishimoto A.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 40
Pages: 347-52
DOI
Related Report
Peer Reviewed
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[Journal Article] Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia2012
Author(s)
Yoshida M, Shiroiwa K, Mouri K, Ishiguro H, Supriyanto I, Ratta-Apha W, Eguchi N, Okazaki S, Sasada T, Fukutake M, Hashimoto T, Inada T, Arinami T, Shirakawa O, Hishimoto A.
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Journal Title
Schizophr Res
Volume: 140(1-3)
Issue: 1-3
Pages: 185-91
DOI
Related Report
Peer Reviewed
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