| Project/Area Number |
23791337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IGA Jun-ichi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (70363140)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | うつ病 / 白血球 / 遺伝子発現 / バイオマーカー / 診断 / PCR |
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| Research Abstract |
[Introduction] The goal of present work was to test the performance of a composite, multi-assay diagnostic test for MDD based on the leukocyte gene expression profiles. [Methods] 25 patients, who met criteria for MDD were eligible for enrollment in this study. 25 non-depressed healthy individuals toserve as a control group were recruited from Tokushima University Hospital. We examined the levels of 40 gene expressions simultaneously using custom-made PCR plate. [Results] 13 gene expressions were significantly changed in MDD. MDD score demonstrated a sensitivity and specificity of 72% and 84%, respectively, in differentiating between MDD patients and healthy subjects. [Discussion] Further research is needed to confirm the performance of the test in other independent samples of patients.
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