| Project/Area Number |
23791345
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
NODA Yoshihiro 東京大学, 医学研究科, 大学院生
SAEKI Takashi 横浜市立大学, 医学研究科, 大学院生
HAYASAKA Shyunsuke 横浜市立大学, 医学研究科, 大学院生
TSUCHIYA Yoshie 横浜市立大学, 医学部, 医局員
IZUNO Takuji 昭和大学, 医学部, 医局員
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 経頭蓋磁気刺激法 / 気分障害 / 背外側前頭前野 / 脳画像 / 脳波 / 神経可塑性 / 反復性経頭蓋磁気刺激法 / ランダム化比較対照試験 / ニューロナビゲーション / 前頭前野 / 薬物治療抵抗性 / 心拍変動 / rTMS |
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| Research Abstract |
We have established a randomized controlled trial (RCT) protocol of repetitive transcranial magnetic stimulation (rTMS) for the medication-resistant patients with major depression, controlled with a sophisticated sham rTMS system. The present RCT design could make it possible to compare different rTMS protocols directly during the acute phase and to examine a prophylactic effect of rTMS during the maintenance phase. As this RCT has not been completed so far, the final analyses, including neurobiological changes induced by consecutive rTMS sessions, are going to be done after the RCT completion.
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